Correlation Between Neovascularization in Atherosclerotic Plaques and Plaque Stability
Objective: To explore the correlation between neovascularization and plaque stability in atherosclerosis (AS). Methods: An AS experimental rabbit model was established, and the model experimental rabbits were randomly divided into blank control group, model group, high-fat diet group, traditional Chinese medicine compound group, and atorvastatin group. Observe the changes in blood lipids in the blank control group and the high-fat diet group at 4, 8, and 12 weeks, use PCR to detect CD34 mRNA expression in tissue specimens, thoracic aorta HE staining results, and neovascular endothelial cell marker CD34 Level changes. Results: Compared with the blank group, T-CHO, TG, and LDL-C in the high-fat diet group increased significantly, and HDL-C decreased significantly (P<0.05); compared with the model group, the quantitative expression results of CD34 mRNA in the high-fat diet group The expression of CD34 in the diet group was increased significantly (P<0.05); HE staining showed that in the high-fat diet group, a large num-ber of foam cells could be seen under the intima to form fibrous plaque lesions; immunohistochemistry showed that in the high-fat diet group, there were endometrium The membrane changes, CD34 staining shows positive expression, and as time goes by, the positive expression gradually increases, and a large number of blue-purple cell nuclei can be seen under the intima, which are CD34-labeled new blood vessels. The new blood vessels in the plaques of experimental rabbits in the high-fat diet group Keep growing. Conclusion: Lipid metabolism disorder, LDL-C, HDL-C levels are related to new blood vessels in plaques. New blood vessels are an important accompanying phenomenon in the progres-sion of AS. AS plaque instability is closely related to new blood vessels in plaques. And there is a positive correlation.
万方数据
维普
