中医药临床杂志2024,Vol.36Issue(2) :372-376.DOI:10.16448/j.cjtcm.2024.0236

中药复方制剂治疗血管性痴呆的临床作用机制

Clinical Mechanism of Chinese Herbal Compound Preparation in the Treatment of Vascular Dementia

李伟盟 李彬 于淼 李冰 刘海妮 范耀宗
中医药临床杂志2024,Vol.36Issue(2) :372-376.DOI:10.16448/j.cjtcm.2024.0236

中药复方制剂治疗血管性痴呆的临床作用机制

Clinical Mechanism of Chinese Herbal Compound Preparation in the Treatment of Vascular Dementia

李伟盟 1李彬 2于淼 2李冰 2刘海妮 3范耀宗1
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作者信息

  • 1. 山东中医药大学 山东济南 250355
  • 2. 山东省青岛市中医医院 山东青岛 266033
  • 3. 山东省青岛市西海岸新区中心医院 山东青岛 266555
  • 折叠

摘要

血管性痴呆(Vascular dementia,VaD)的发病率随着社会人口老龄化加重而逐年上升,其发病机制复杂,主要与中枢胆碱系统功能障碍、炎症反应、氧化应激、细胞凋亡、肠道菌群失调、神经毒性等因素密切相关.近年来,中药复方在临床上被广泛应用,具有多靶点、不良反应少的优势.VaD发病机理与防治药物的研究具有重要社会价值,因此文章系统综述国内外关于中药复方制剂治疗VaD的文献,对其发病机制及方药的临床作用机理进行了归纳与总结.

Abstract

The incidence of vascular dementia (VaD) is increasing year by year with the aging of the social popula-tion. Its pathogenesis is complex and is mainly related to central choline system dysfunction, inflammatory response, oxidative stress, apoptosis, intestinal Tract flora dysbiosis, neurotoxicity and other factors are closely related. In recent years, traditional Chinese medicine compounds have been widely used clinically, with the advantages of multiple targets and few adverse reactions. Research on the pathogenesis of VaD and preventive and therapeutic drugs has important social value. Therefore, this article systematically reviews the domestic and foreign literature on the treatment of VaD with traditional Chinese medicine compound preparations, and summarizes its pathogenesis and clinical action mecha-nism of the prescriptions.

关键词

血管性痴呆/中医药/方剂/作用机制

Key words

Vascular dementia/Traditional Chinese medicine/Prescription/Mechanism of action

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基金项目

山东省中医药科技发展计划项目(2019-0593)

出版年

2024
中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
参考文献量8
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