Mechanism of Radix Salviae-Curcumae Rhizoma in Treating Cancer-related Anorexia
Objective: Use network pharmacology and molecular docking to study the mechanism of action of Sal-via miltiorrhiza - Curcuma zedoaria in the treatment of cancer-related anorexia (CA). Methods: The target genes were screened out through the TCMSP database, Uniprot database, PharmMapper database and combined with relevant litera-ture, and the Genecards database and OMIM database were used to obtain and screen the corresponding targets of CA. Use the String database to construct a protein interaction network of intersection targets between diseases and drugs, and import the results into cytoscape3.8.2 software for visual analysis. The intersection genes obtained from the String database were then subjected to GO enrichment analysis and KEGG enrichment pathway analysis through the Metascape database. Autodock software was used for molecular docking, and pymol software was used for visualization. Results: A total of 126 Salvia miltiorrhiza targets, 54 Curcuma zedoaria targets, 25 common targets, 1893 CA targets, and 14 disease-drug inter-section targets were obtained. Protein interaction results show that MAPK1 and ESR1 are core targets. Biological processes in GO enrichment analysis mainly involve cell response to organic cyclic compounds, steroid hormone-mediated signaling pathways, steroid hormone responses, etc.; KEGG enrichment pathways mainly involve Estrogen signaling pathway, TNF signaling pathway, etc. Molecular docking shows that the core target has good binding ability with drug ingredients. Con-clusion: Salvia miltiorrhiza and Curcuma zedoaria can treat CA by regulating the Estrogen signaling pathway, TNF signal-ing pathway and other signaling pathways through the core targets of MAPK1 and ESR1.
Salvia miltiorrhizaCurcuma zedoaryaCancer anorexiaNetwork pharmacologyMolecular docking
万方数据
维普
