Effects of Buyuan Congao Decoction combined with Piracetam on Blood-brain Barrier, Cognitive Function, Serum IGF-1 and Aβ in Senile Dementia Patients
Objective: To explore the effects of Buyuan Congnao decoction combined with piracetam on blood-brain barrier, cognitive function and serum IGF-1 and Aβ in patients with Alzheimer's disease due to kidney deficiency and blood stasis type. Methods: 196 cases of Alzheimer's patients with kidney deficiency and blood stasis type who were treated from March 2020 to March 2023 were selected as the research subjects and divided into an observation group and a control group according to the random number table method, with 98 cases in each group. The observation group was treated with Buyuancongnao Decoction + Piracetam, and the control group was treated with Piracetam. Com-pare the efficacy, TCM syndrome scores, and cognitive function indicators between the two groups before treatment and after 3 months of treatment [AD Rating Scale-Cognitive Subscale (ADAS-Cog), Mini-Mental State Examination (MMSE) score], blood-brain barrier related indicators [serum albumin (ALB), cerebrospinal fluid ALB, cerebrospinal fluid ALB/serum ALB ratio (QALB)], biochemical factor indicators [insulin-like growth factor-1 (IGF-1), beta amyloid (Aβ)] and adverse reactions. Results: The effective rate of the observation group (91.84％) was higher than that of the control group (75.51％); after 3 months of treatment, the TCM syndrome score and ADAS-Cog score of the observation group were lower than those of the control group, and the MMSE score was higher than that of the control group; Treatment 3 After 3 months of treatment, the serum ALB, cerebrospinal fluid ALB, and QALB levels of the observation group were lower than those of the control group; after 3 months of treatment, the IGF-1 level of the observation group was higher than that of the control group, and the Aβ level was lower than that of the control group, and the differences were sta-tistically significant. Conclusion: Buyuan Congnao decoction combined with piracetam is effective in treating patients with AD. It can effectively reduce the permeability of the blood-brain barrier, protect neuronal cells, and is safe and reliable, which is beneficial to promoting the recovery of patients' cognitive functions.
Buyuan Congnao DecoctionPiracetamAlzheimer's diseaseBlood-brain barrierCognitive function
万方数据
维普
