Effect of Hepatic Function Changes after Splenectomy on Spleen Deficiency Syndrome and Intervention of Chinese Herbs for Invigorating Spleen and Activating Blood Circulation
Objective: To observe the changes of liver function in hepatolenticular degeneration (HLD) patients with splenomegaly and hypersplenism undergoing splenectomy and its effect on the formation of spleen deficiency syn-drome, and to explore the intervention effect of traditional Chinese medicine for strengthening spleen and activating blood circulation. Methods: a total of 80 HLD patients with splenomegaly and hypersplenism undergoing splenectomy were randomly divided into observation group (n = 40) and control group (n = 40), and the influence of liver function on the formation of spleen deficiency syndrome in HLD patients undergoing splenectomy was analyzed by univariate analysis. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL) and albumin (ALB) were observed before and after treatment. The symptom scores of the pa-tients with spleen deficiency syndrome in the two groups (35 cases in the observation group and 29 cases in the control group) were compared. Results: The results of univariate analysis showed that the levels of ALT, AST, TBIL before operation and the first day after operation and ALB before operation were significantly related to the formation of spleen deficiency syndrome (P＜0.05); There was no significant difference in liver function indexes between the two groups before operation and on the first and seventh day after operation (P > 0.05), but on the fourteenth day after operation, the levels of ALT, AST and DBIL in the observation group were significantly lower than those in the control group (P＜0.05), and the level of ALB was significantly higher (P＜0.05). The observation group was significantly better than the control group in the treatment of spleen deficiency syndrome with Jianpi Huoxue Chinese medicine, the difference was statistically significant (P＜0.05). Conclusion: Preoperative and early postoperative liver function is an important factor in the formation of spleen deficiency syndrome in patients with HLD after splenectomy, and the traditional Chi-nese medicine for strengthening spleen and activating blood circulation can significantly promote the recovery of liver function after splenectomy, and has a definite effect on the improvement of spleen deficiency syndrome.
splenectomyliver functionspleen deficiency syndromeinvigorating spleen and activating blood cir-culation
万方数据
维普
