首页|子宫内膜异位症相关古籍的用药规律分析

子宫内膜异位症相关古籍的用药规律分析

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目的:分析古籍中治疗子宫内膜异位症(Endometriosis,EM,简称内异症)相关病症的用药规律,为临床应用古方治疗EM提供依据.方法:确定检索词,搜索《中华医典》、中医药大数据智能处理与知识服务系统相关文献,采用Excel2021进行药物性味、归经、频数统计分析;SPSS Statistics 26.0统计软件进行药物聚类分析;运用SPSS Modeler 18.0 Apriori算法对高频中药进行关联规则分析.结果:共筛选出468首处方、277味中药.药性以温、平为主;药味以辛、甘为主;药物多入肝、脾经;当归、白芍、川芎、熟地黄、甘草、香附、延胡索、肉桂等药物频数较高;得出4个药物聚类、15个药物关联规则及一个常用方.结论:EM相关古籍的组方多以补虚药、活血化瘀药为主,可为现代诊疗子宫内膜异位症提供用药思路.
Analysis of Medication Rules in Ancient Books on Endometriosis based on Data Mining
Objective: To analyze the medication rules for treating endometriosis (EM, referred to as endometriosis)-related diseases in ancient books, and to provide basis for the clinical application of ancient prescriptions in the treat-ment of EM. Methods: Determine the search terms, search the "Chinese Medical Dictionary", Chinese Medicine Big Data Intelligent Processing and Knowledge Service System related literature, use Excel2021 to conduct statistical analysis of drug properties, taste, meridian tropism, and frequency; use SPSS Statistics 26.0 statistical software to con-duct drug cluster analysis ; Use SPSS Modeler 18.0 Apriori algorithm to conduct association rule analysis on high-frequency traditional Chinese medicines. Results: A total of 468 prescriptions and 277 traditional Chinese medicines were screened out. The properties of the medicine are mainly warm and mild; the taste is mainly pungent and sweet; most medicines enter the liver and spleen meridian; the frequency of medicines such as angelica root, white peony root, chuanxiong rhizome, rehmannia glutinosa, licorice, cyperus rotundus, Corydalis corydalis, and cinnamon is higher; it can be concluded that 4 drug clusters, 15 drug association rules and a common prescription. Conclusion: The prescrip-tions in EM-related ancient books are mostly based on tonic and blood-activating and blood-stasis-removing drugs, which can provide medication ideas for modern diagnosis and treatment of endometriosis.

EndometriosisAncient booksMedication rulesData mining

蔡舒雅、陈浩、王永霞、曹立幸

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广州中医药大学第二临床医学院 广东广州 510120

广州中医药大学 广东广州 510405

子宫内膜异位症 古籍 用药规律 数据挖掘

广东省哲学社会科学规划项目广东省自然科学基金广东省中医药局科研项目

GD20LMZTS052023A151501110920211119

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(4)
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