首页|肝豆补肾汤治疗男性肝豆状核变性合并生殖损害的理想点法综合疗效评价研究

肝豆补肾汤治疗男性肝豆状核变性合并生殖损害的理想点法综合疗效评价研究

扫码查看
原文链接
  • 万方数据
  • 维普
目的:使用理想点法(TOPSIS法)综合评价肝豆补肾汤对男性肝豆状核变性合并生殖损害患者的临床疗效,为规范治疗男性肝豆状核变性合并生殖损害提供临床依据.方法:基于前期构建的肝豆状核变性疗效评价体系以及对男性肝豆状核变性合并生殖损害的临床调查和文献研究,制定专家调查问卷.通过德尔菲法(Delphi法)对结局指标进行赋权,确定权重系数.将60例男性肝豆状核变性合并生殖损害患者随机分为对照组和试验组各30例.对照组:西医常规排铜治疗(5％葡萄糖注射液250mL+二巯丙磺钠注射液20mg/kg,1次/d,连续静滴6d;间歇期2d予以葡萄糖酸钙注射液补钙).试验组:在对照组的基础上予肝豆补肾汤治疗(1剂/d,早晚分服).疗程:8d为1疗程,连续治疗4个疗程.应用TOPSIS法对60例男性肝豆状核变性合并生殖损害患者的结局指标进行临床疗效综合评价.结果:试验组的相对接近程度C值(0.878),高于对照组(0.122),更接近于最优治疗方案.结论:该研究表明肝豆补肾汤结合西药治疗男性肝豆状核变性合并生殖损害患者的临床疗效明显优于单纯西药治疗.
Comprehensive efficacy evaluation with TOPSIS method in the treatment of male Hepatolenticular Degeneration combined with reproductive damage by Gandou Bushen Tang
Objective: To evaluate the clinical efficacy of the Gandou Bushen Tang (GDBST) in male Hepatolen-ticular Degeneration (HLD) combined with reproductive damage using the Technique for Order Preference by Similar-ity to Ideal Solution (TOPSIS) method. Methods: Based on pre-developed HLD clinical efficacy evaluation system, an expert questionnaire was developed through a clinical survey and literature study of male HLD combined with repro-ductive damage. The Delphi method assigned the outcome indicators weights to determine the weight coefficients. Sixty male patients with HLD combined with reproductive damage were randomly divided into 30 cases each in the control group and the experimental group. Control group: conventional copper-chelating treatment (250ml of 5％ glucose in-jection + sodium dimercaptopropane sulfonate injection, 20mg/kg/d, once daily for 6 consecutive days. During the in-termission, calcium gluconate injection was used to supplement calcium for 2 consecutive days). Experimental group: based on the control group, GDBST was given (1 dose per day, divided in the morning and evening). Course of treat-

Hepatolenticular degenerationGandou Bushen Tangreproductive damageTOPSIS methodcom-

赵丹、韩辉、房新如、王路瑶、刘千琢、吴丽敏

展开 >

安徽中医药大学第一附属医院 安徽合肥 230031

中国科学技术大学附属第一医院生殖中心 安徽合肥 230001

肝豆状核变性 肝豆补肾汤 生殖损害 理想点法 综合疗效评价

国家自然科学基金安徽省科技厅临床专项转化项目安徽省教育厅重点项目安徽省创新创业领军人才特殊支持计划安徽省红十字会中医药传承创新项目

823742122022042951070200442022AH050523组通字[2014]35号2022ZYYD24

2024

10.16448/j.cjtcm.2024.0428

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子：0.636
ISSN：1672-7134
年,卷(期)：2024.36(4)
  • 32