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真实世界中药治疗卒中相关性肺炎的用药规律分析

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目的:分析真实世界中药治疗卒中相关性肺炎的用药特点,为总结归纳验方提供基础.方法:检索天津中医药大学第一附属医院针灸优势病种健康医疗研究型数据库2019年1月—2022年12月的住院患者,并使用Excel 2021、IBM SPSS modle 18.0、SPSS Statistics 27.0对数据进行频次分析、关联规则分析及聚类分析.结果:纳入385例接受中药治疗的卒中相关性肺炎(stroke-associated pneumonia,SAP)患者,涉及中药276味,高频药物分析得出SAP的治疗繁杂,基本包含补气、补血、补阴、补阳、燥湿化痰、清热泻火、活血化瘀等药物;关联规则分析表明根据中风病临床特点,使用天麻钩藤饮、半夏白术天麻汤治疗SAP的情况更多;聚类分析则进一步验证了半夏白术天麻汤在治疗SAP上的多用性.结论:SAP以"痰、热、虚"为病理特点,临床最常见的证型为痰热壅肺证,以上数据挖掘方法均表明半夏白术天麻汤为治疗SAP的常用方.
Analysis of Medication Rules of Traditional Chinese Medicine in the Treatment of Stroke Associated Pneumonia in the Real World
Objective: To analyze the characteristics of traditional Chinese medicine in the treatment of stroke-re-lated pneumonia in the real world and provide a basis for summarizing prescriptions. Methods: Search the Acupuncture Predominant Disease Health and Medical Research Database of the First Affiliated Hospital of Tianjin University of Chinese Medicine for inpatients from January 2019 to December 2022, and use Excel 2021, IBM SPSS modle 18.0, and SPSS Statistics 27.0 to frequency the data analysis, association rule analysis and cluster analysis. Results: 385 patients with stroke-associated pneumonia (SAP) who were treated with traditional Chinese medicine were included, involving 276 flavors of traditional Chinese medicine. High-frequency drug analysis showed that the treatment of SAP is com-plex and basically includes nourishing qi, nourishing blood, nourishing yin, and nourishing yin. Yang, dampness and phlegm, clearing heat and purging fire, promoting blood circulation and removing blood stasis; association rule analy-sis shows that according to the clinical characteristics of stroke, more cases of using Gastrodia Gouteng Decoction and Banxia Atractylodes Tianma Decoction to treat SAP; cluster analysis further The versatility of Banxia Atractylodes and Tianma Decoction in treating SAP was verified. Conclusion: SAP is pathologically characterized by "phlegm, heat, and deficiency", and the most common clinical syndrome is phlegm-heat blocking the lungs. The above data mining meth-ods show that Banxia Atractylodes Tianma Decoction is a commonly used prescription for the treatment of SAP.

Stroke-related pneumoniaData miningReal worldMedication rules

吴金玲、吴柯玫、金鑫、杨霖轩、尹丽丽

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天津中医药大学第一附属医院,国家中医针灸临床医学研究中心 天津 300381

天津中医药大学 天津 301617

卒中相关性肺炎 数据挖掘 真实世界 用药规律

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(4)
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