Risk Factors of Early Neurological Deterioration in Acute Atherosclerotic Stroke and the Effect of Combined Application of Huangqi Guizhi Wuwu Granule
Objective: To explore the risk factors for early neurological deterioration in acute large-artery athero-sclerotic stroke, and to explore the therapeutic effect of Huangqi Guizhi Wuwu Granules. Methods: Regression analysis was conducted on the clinical data of 182 patients with acute large artery atherosclerotic stroke admitted to the Seventh People's Hospital of Zhengzhou from August 2022 to February 2023, and according to the National Institutes of Health Stroke Scale (NIHSS) The scores divided the patients into neurological deterioration group (47 cases) and non-neuro-logical deterioration group (135 cases). The clinical data of the two groups of patients were statistically compared, and single-factor and multi-factor logistic regression analyzes were performed to screen out risk factors that affect the early neurological deterioration of acute large-artery atherosclerotic stroke. All patients were divided into group A (91 cases, treated with argatroban injection) and group B (91 cases, treated with argatroban injection + Huangqi Guizhi Wuwu granules) according to different treatment methods. The treatment cycle was 2 week. Compare the neurological function and inflammatory factor levels of patients in Group A and Group B before and after treatment. Results: Single-factor results showed that the proportion of patients with atrial fibrillation, diabetes, and carotid artery stenosis ≥ 50％ in the neurological deterioration group was higher than that in the non-neurological deterioration group, and white blood cell count (WBC) and high-sensitivity C-reactive protein (hs-CRP) The level was higher than that of the non-neurological deterioration group (P<0.05); in multivariate logistic regression analysis, the results showed that atrial fibrillation, dia-betes, carotid artery stenosis ≥ 50％, WBC, and high hs-CRP levels were all factors affecting acute large artery ath-erosclerosis. Independent risk factors for early neurological deterioration in sclerosing stroke (OR value=7.652, 3.501, 5.286, 4.586, 6.495) (P<0.05); Compared with group A before treatment, group B found that after clinical treatment, the National Health Research The hospital stroke scale (NIHSS) score, WBC, and hs CRP levels were reduced (P<0.05). Conclusion: Atrial fibrillation, diabetes, carotid artery stenosis ≥ 50％, high WBC and hs-CRP levels are independent risk factors for early neurological deterioration of acute large-artery atherosclerotic stroke, which can be treated with Huangqi Guizhi Wuwu Granules. It can improve patients' neurological function, reduce inflammatory response, reduce brain tissue damage, and protect brain tissue.
万方数据
维普
