Clinical Observation of Chronic Atrophic Gastritis in Spleen and Gastric Weakness Type Anxiety and Modified Guipi Decoction and Weifuchun Decoction
Objective: To observe the clinical efficacy of modified Guipi Decoction combined with Weifuchun in the treatment of spleen and stomach weakness type chronic atrophic gastritis (CAG) accompanied by anxiety. Explore the clinical value and potential mechanism of action of this drug to provide a reference for clinical treatment. Methods: A total of 80 CAG patients with anxiety who met the inclusion requirements were observed, and they were randomly di-vided into a control group and a treatment group of 40 cases each. The control group was treated with Weifuchun, and the treatment group was treated with Jiajia Guipi Decoction combined with Weifuchun. The treatment course for both groups was 8 weeks. After 8 weeks of treatment, the TCM syndrome scores, TCM syndrome efficacy, Hamilton Anxi-ety Scale (HAMA) score, gastroscopy symptom score, pathology score, serum gastrin 17 (G-17), pepsinogen I (PGI), pepsinogen I/Ⅱ ratio (PGR) and safety evaluation. Results: The efficacy of TCM symptoms: compared with the control group, the total effective rate was 75.00％, and the treatment group's total effective rate was 92.50％, which showed that it was better than the control group (P<0.05). TCM syndrome scores: After 8 weeks of treatment, the TCM syndrome scores of both groups decreased compared with before. Comparing the changes in TCM syndrome scores before and after treatment, the treatment group was more obvious (P<0.05). Pathological score: The presence or absence of inflamma-tion, atrophy, intestinal metaplasia, and dysplasia is divided into four severity levels: none, mild, moderate, and severe, recorded as 0, 1, 2, and 3 points. After treatment in both groups The total points of each item were recorded, indicating that the treatments in both groups were effective (P<0.05), and the treatment effect of the treatment group was signifi-cantly higher than that of the control group (P<0.05). Serum G-17, PGI, and PGR levels: After treatment, the levels of G-17, PGI, and PGR in both groups of patients increased compared with before (P<0.05), and the increase in the treat-ment group was greater than that in the control group (P<0.05). Hamilton Anxiety Scale (HAMA) score: After treatment, the anxiety scale scores of the two groups of patients were lower than before treatment (P<0.05). The difference between the two groups after treatment was statistically significant (P<0.05). It means that the treatment group can improve anx-iety better than the control group. Conclusion: Jiajian Guipi Decoction combined with Weifuchun can significantly im-prove the patients' TCM symptoms, psychological state, gastric mucosal status and pathological scores, and effectively regulate serum G-17, PGI and PGR when treating patients with spleen and stomach weakness CAG accompanied by anxiety level, compared with the control group, the efficacy is better, and the treatment is safe, with no adverse events.
Jiajia Guipi DecoctionChronic atrophic gastritis with anxietySpleen and stomach weakness type
万方数据
维普
