Effect of Zanthoxylum suppository on wound healing and wound microenvironment after anal fistula operation
Objective: To observe the effect of Zanthoxylum bungeanum suppository on anal fistula wound healing and the effect of Zanthoxylum bungeanum suppository on wound micro-environment. Methods: From November 2020 to November 2021, 60 patients with high-level simple anal fistula who were admitted to Nanjing Traditional Chinese Medicine Hospital and underwent surgical treatment were divided into 2 groups using a randomized and controlled clinical research method, with 30 cases in each group. The control group received routine After disinfection, sterile petroleum jelly gauze was used for dressing change. The treatment group added 1 Zanthoxylum bungeanum suppository to the control group. The pain, granulation growth, wound exudation, wound shrinkage, and wound surface 9 days after surgery were compared between the two groups. Complete healing time and expression levels of inflammatory factors and matrix metalloproteinases (MMPs). Results: On the 2nd and 9th day after surgery, the pain scores in the treatment group were all < those in the control group (P<0.05). In terms of wound healing, the granulation growth and exudation of the postoperative wound in the treatment group were better than those in the control group (P<0.05). The granula-tion growth was vigorous and the wound exudation was less. The wound shrinkage rate of the treatment group was sig-nificantly higher than that of the control group, completely. The healing time was shorter than that of the control group (P<0.05); 9 days after surgery, the levels of Interleukin-6 (IL-6), tumor necrosis factor -α(TNF-α), matrix metallo-proteinase-9 (MMP9) and matrix metalloproteinase-2(MMP2) detected by Western Blot in the wounds of the treatment group were lower than those of the control group. Conclusion: The application of Zanthoxylum bungeanum suppository on the basis of routine dressing change can significantly reduce the postoperative pain of patients, effectively reduce the expression levels of IL-6, TNF-α, MMP9, and MMP2 in the wound microenvironment, promote wound healing after anal fistula surgery, and shorten the time of postoperative pain. Course of disease.
万方数据
维普
