Research Progress on Pathological Mechanisms and Traditional Chinese Medicine Interventions of Bronchial Asthma Based on TRPA1 Ion Channel Protein
Asthma is a chronic inflammatory disease of the airways characterized by recurrent airway obstruction and wheezing. Transient Receptor Potential Al (TRPA1) ion channels exist in a variety of tissue cells and are involved in regu-lation. Airway function and inflammation. Previous research on TRPA1 was mostly in the field of pain, and the pathological mechanism of related regulation of ion protein channel expression in the treatment of bronchial asthma and the progress of traditional Chinese medicine treatment have not yet been systematically elucidated. A review of relevant literature at home and abroad found that during the occurrence and development of asthma, the TRPA1 ion channel protein is involved in pathological processes such as airway inflammation and airway hyperresponsiveness. Therefore, regulating the expres-sion of TRPA1 ion protein channel is beneficial to the treatment of bronchial asthma. At present, the treatment methods of Western medicine are mainly combined with inhaled glucocorticoids and bronchodilators, but some patients cannot achieve complete control. Traditional Chinese medicine has the characteristics of multiple targets, wide range of effects, and excellent curative effect in the treatment of asthma. Traditional Chinese medicine and compound prescriptions for asthma, Xuanfei and Qi can effectively regulate the expression of TRPA1 in the body through anti-inflammatory and other effects. This article summarizes the TRPA1 ion channel protein and its relationship with bronchial asthma, and reviews the research progress of traditional Chinese medicine in regulating the expression of TRPA1 in the treatment of bronchial asthma in recent years, in order to lay a laboratory foundation for exploring new pathological mechanisms of bronchial asthma based on TRPA1, and provide guidance for bronchial asthma. The prevention and treatment of asthma and the de-velopment of related new traditional Chinese medicines provide new targets and research directions.
AsthmaTransient receptor potential ankyrin 1 ion channelInflammationTraditional Chinese medicine
万方数据
维普
