Pulmonary fibrosis (PF) is a chronic, fibrotic interstitial respiratory disease of unknown cause. Its forma-tion process is very complex, its pathogenesis has not been fully elucidated, and there is currently no effective treat-ment. In recent years, many studies have found that endoplasmic reticulum stress (ERS) is closely related to the occur-rence and development of PF. This article discusses the research progress of domestic and foreign scholars in recent years on the mechanism of endoplasmic reticulum stress in PF. To summarize, it mainly focuses on the aspects of ERS restoring endoplasmic reticulum homeostasis through cascade reactions and three classic signaling pathways, the rela-tionship between epithelial-mesenchymal transition and ERS, inhibiting ERS to delay the process of PF, and Chinese and Western medicine regulating ERS to delay PF, etc. This review and summary is intended to provide reference for in-depth research on the pathogenesis, clinical diagnosis and treatment of PF.
关键词
肺纤维化/内质网应激/上皮间质转化/未折叠蛋白反应
Key words
Pulmonary fibrosis/Endoplasmic reticulum stress/Epithelial mesenchymal transition/Unfolded protein response
维普
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