首页|基于内质网应激反应探究针刺治疗卒中后抑郁的机制

基于内质网应激反应探究针刺治疗卒中后抑郁的机制

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
卒中后抑郁(Post Stroke Depression,PSD)发生在脑卒中后,以情感低落、兴趣丧失、自我价值感下降、睡眠障碍等症状为主要临床表现.为探究针刺治疗PSD的具体分子机制,作者通过查阅近年来PubMed、CNKI、万方、维普等国内外数据库的资料和文献,将PSD与内质网应激反应(endoplasmic reticulum stress,ERS)的关系及针刺通过干预ERS来治疗PSD的临床研究和动物实验研究进行总结分析,厘清ERS的发生机制以及针刺干预ERS的可能靶点.该文章得出推论,针刺可能通过调节ERS相关通路蛋白,抑制炎症反应及超负荷ERS介导的细胞凋亡来改善PSD患者的临床症状.因此,该研究将针刺治疗手段调控PSD后发生ERS的相关靶点机制进行归纳,以期日后为针刺治疗PSD的可探索靶点方向提供新的思路及一定的科学依据.
Based on Endoplasmic Reticulum Stress Response to Discusses the Mechanism of Acupuncture Treatment for Post-stroke Depression
Post-stroke depression(PSD)occurs after stroke,with symptoms such as depression,loss of interest,decreased self-worth,and sleep disturbance as its main clinical manifestations.In order to explore the specific mo-lecular mechanism of acupuncture treatment of PSD,the author reviewed the information and literature in domestic and foreign databases such as PubMed,CNKI,Wanfang,and VIP in recent years,and compared the relationship between PSD and endoplasmic reticulum stress(ERS).This paper summarizes and analyzes the clinical research and animal ex-perimental studies on the relationship between acupuncture and ERS to treat PSD,and clarifies the mechanism of ERS and the possible targets of acupuncture to intervene in ERS.This article concluded that acupuncture may improve the clinical symptoms of PSD patients by regulating ERS-related pathway proteins,inhibiting inflammatory responses and overloading ERS-mediated apoptosis.Therefore,this study summarizes the relevant target mechanisms of ERS after acupuncture treatment regulates PSD,with a view to providing new ideas and certain scientific basis for the explorable target directions of acupuncture treatment of PSD in the future.

Post-Stroke depressionEndoplasmic reticulum stress responseAcupunctureEye acupunctureUn-folded protein responseMechanism of actionSame treatment for different diseases

杨明岳、海英

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辽宁中医药大学 辽宁沈阳 110847

辽宁中医药大学附属医院 辽宁沈阳 110847

卒中后抑郁 内质网应激反应 针刺 眼针 未折叠蛋白反应 作用机制 异病同治

辽宁省"兴辽英才计划"项目广东省新黄埔中医药联合创新项目

XLYC20021042022IR002

2024

10.16448/j.cjtcm.2024.0503

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子：0.636
ISSN：1672-7134
年,卷(期)：2024.36(5)
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