Clinical Study of Anti-PLA2R Antibody,Hp and TCM Syndrome Type in IMN Patients
Objective:To explore the clinical characteristics of anti-phospholipase A2 receptor(PLA2R)antibod-ies,Helicobacter pylori(Hp)and TCM syndrome types in patients with idiopathic membranous nephropathy(IMN).Methods:Clinical data on anti-PLA2R antibodies,Hp detection,and TCM syndrome distribution of 57 IMN patients were collected,and data processing and analysis were performed.Results:The TCM syndrome types of 57 patients with IMN were lung and kidney qi deficiency syndrome,spleen and kidney Qi deficiency syndrome,spleen and kidney yang deficiency syndrome,and liver and kidney yin deficiency syndrome.Among them,spleen and kidney Qi deficiency syndrome could be found in different pathological stages of IMN;in lung and kidney syndrome,Among patients with Qi deficiency syndrome,spleen and kidney Qi deficiency syndrome,spleen and kidney Yang deficiency syndrome,and liver and kidney Yin deficiency syndrome,the positive rates of anti-PLA2R antibodies were 73.7%,72%,75%,and 80%respectively;membranous nephropathy(MN)Ⅱ Among patients with stage 1 and MN stage Ⅲ,the positive rates of anti-PLA2R antibodies were 77.3%and 70%respectively;among patients with lung and kidney Qi deficiency syn-drome,spleen and kidney Qi deficiency syndrome,and spleen and kidney Yang deficiency syndrome,the Hp positive rates were 63.2%and 68%,respectively.%,75%;the Hp positive rates in patients with MN stage Ⅱ and MN stage Ⅲ were 63.6%and 60%respectively.Conclusion:Spleen and kidney Qi deficiency syndrome is the main TCM syndrome type of IMN;anti-PLA2R antibody positivity can be seen in different pathological stages of IMN and various TCM syn-drome types;the positive rate of anti-PLA2R antibodies increases with the evolution of TCM syndrome types,and anti-PLA2R antibody positivity increases with the evolution of TCM syndrome types.Testing combined with TCM syndrome types can be used to evaluate the condition of IMN;the HP positive rate is higher in different pathological stages of IMN and different TCM syndrome types,and the HP infection rate has a significant increasing trend with the evolution of TCM syndrome types.In the process of traditional Chinese and Western medicine treatment,it is necessary to raise awareness of the importance of anti-Hp treatment.
Idiopathic membranous nephropathyAnti-phospholipase A2 receptor antibodyHelicobacter pyloriPathological stagingTraditional Chinese medicine syndrome types
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