The Efficacy of Zisheng Qingyang Decoction in Preventing and Treating Early Renal Damage in Hypertension and its Impact on Blood Pressure Circadian Rhythm
Objective:To observe the efficacy of Zisheng Qingyang Decoction of Menghe Medical School in prevent-ing and treating early renal damage of hypertension and its effect on the circadian rhythm of blood pressure.Methods:80 patients who met the criteria and were diagnosed with early renal damage due to hypertension were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given routine treat-ment with Olmesartan and Amlodipine,while the observation group was given Zisheng Qingyang Decoction on the basis of the control group.The clinical efficacy,TCM symptom efficacy,and cystatin C(Cys-C),urinary mAlb,and urinaryβ-microglobulin levels were compared between the 2 groups.Results:The total effective rate of TCM symptoms in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the levels of Cys-C,urinary β-microglobulin and urinary mAlb between the two groups before treatment(P＞0.05);after 8 weeks of treatment,the levels of Cys-C,urinary β-microglobulin and urinary mAlb in the observation group were all the same.Lower than the control group,the difference was statistically signifi-cant(P＜0.05).Intra-group comparison between the 2 groups showed that after 8 weeks of treatment,the levels of Cys-C,urinary β-microglobulin and urinary mAlb in the control group and the observation group were lower than before treatment,and the differences were statistically significant(P＜0.05).There was no difference in blood pressure levels between the two groups of patients before treatment.After treatment,the 24-h average systolic blood pressure and 24-h average diastolic blood pressure levels of the observation group were lower than those of the control group;there was no difference in the circadian rhythm of blood pressure between the two groups of patients before treatment.After treat-ment,the observation group had a dipper type The blood pressure in patients was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion:Zisheng Qingyang Decoction combined with con-ventional Western medicine treatment has a good therapeutic effect on early-stage hypertensive renal damage.It can significantly improve patients'traditional Chinese medicine symptoms and renal function,and can also regulate the circadian rhythm of blood pressure,which is worthy of clinical recommendation.
Menghe Medical SchoolZisheng Qingyang DecoctionEarly renal damage of hypertensionCircadian rhythm of blood pressure
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