Basic Research Progress of Traditional Chinese Medicine in Preventing and Treating Flap Ischemia Reperfusion Injury
Skin flap repair is one of the main ways to treat skin defects in current trauma and plastic surgery,and it plays an important role in burns,trauma repair,and cosmetic plastic surgery.Flap ischemia reperfusion injury(FIRI)is the most serious complication after skin flap transplantation.The continuous aggravation of FIRI can eventually lead to skin flap necrosis,seriously affecting the therapeutic effect after skin flap repair.As one of the important means of treating diseases with traditional Chinese medicine,under the guidance of traditional Chinese medicine theory,tradi-tional Chinese medicine plays an important role in the prevention and treatment of FIRI through its"holistic view,in-dividualization,and treatment before disease"and its characteristics and advantages of wide action pathways,multiple targets,and rich levels.important position.Previous studies have found that the mechanism of action of traditional Chi-nese medicine in preventing and treating FIRI mainly includes reducing the production of inflammatory factors,allevi-ating oxidative stress,promoting angiogenesis,and enhancing autophagy.This article reviews the mechanism of action and related research progress of traditional Chinese medicine in the prevention and treatment of FIRI from the above aspects,aiming to provide theoretical basis and reference for further research on the action mechanism and application value of traditional Chinese medicine in the prevention and treatment of FIRI.
Traditional Chinese medicineSkin flapIschemia-reperfusion injuryInflammatory responseOxidative stressAngiogenesisAutophagy
国家科技期刊平台
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