摘要
目的:运用数据挖掘技术探究并总结韩明向教授辨治郁证的用药经验.方法:收集韩明向门诊郁证患者的病例,运用Excel软件建立数据库,对病人年龄、性别、辨证证型、以及高频药物进行统计学分析,并用SPSS软件进行关联规则分析、频数项集分析、聚类分析.结果:共收录处方108例,好发人群为绝经期前后的女性和中青年及中年男性,证型最多的为气郁化火证.涉及药物189味,高频药物包括柴胡、当归、白芍、甘草、牡丹皮、栀子等;常用药对有茯神-合欢皮、酸枣仁-合欢皮、栀子-牡丹皮等;常用药物组合有酸枣仁、柴胡-合欢皮,茯神、夏枯草-合欢皮,茯神、栀子-合欢皮等.聚类分析得出栀子-牡丹皮-当归-白芍-柴胡、合欢皮-茯神-夏枯草等4个药物聚类组合.结论:韩明向教授秉承"治病必求于本"的学术思想,抓住郁证中气郁之关键,结合当代好发人群的生理及外在特点,从郁、气、火三方面形成行气解郁,疏肝泻火为主要治疗准则的临床经验.
Abstract
Objective:To explore and summarize Professor HAN Mingxiang's experience in using drugs to treat de-pression using data mining technology.Methods:Cases of depression patients in HAN Mingxiang's outpatient clinic were collected,and a database was established using Excel software.The age,gender,syndrome type,and high-fre-quency drugs of the patients were statistically analyzed.SPSS software was used for association rule analysis,frequency item set analysis,and cluster analysis.Results:A total of 108 prescriptions were included.The most common popula-tions were women before and after menopause and young and middle-aged men.The most common syndrome was Qi stagnation and fire syndrome.A total of 189 drugs were involved.The high-frequency drugs included bupleurum,an-gelica,white peony root,liquorice,peony bark,gardenia,etc.;the commonly used drug pairs included poria-albizzia bark,jujube seed-albizzia bark,gardenia-peony bark,etc.;the commonly used drug combinations included jujube seed,bupleurum-albizzia bark,poria,prunella vulgaris-albizzia bark,poria,gardenia-albizzia bark,etc.Cluster analysis resulted in four drug cluster combinations:Gardenia-Peony Root-Angelica-White Peony Root-Bupleu-rum,Albizzia julibrissin-Poria-Prunella Vulgaris.Conclusion:Professor HAN Mingxiang adheres to the academic thought of"the root of the disease must be sought",grasps the key of Qi stagnation in depression,combines the physi-ological and external characteristics of the contemporary susceptible population,and forms clinical experience of pro-moting Qi and relieving depression,soothing the liver and purging fire as the main treatment principles from the three aspects of depression,Qi and fire.
基金项目
2023年度安徽省卫生健康科研项目(AHWJ2023A20281)
第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号)
2022年中国民族医药学会科研项目(2022Z1002-450813)
2022年度安徽省中医药传承创新项目(2022CCZD01)
国家科技期刊平台
NSTL
万方数据