Clinical Significance and Correlation Analysis of expression of Lipoprotein(a)in Patients with Phlegm Stasis Interjunction Cerebral Infarction
Objective:To explore the clinical significance and correlation of lipoprotein(a)(LP)expression in pa-tients with cerebral infarction(CI)with phlegm and blood stasis.Methods:A total of 302 CI patients hospitalized in the Department of Geriatrics,the Second Affiliated Hospital of Anhui University of Chinese Medicine from January 2022 to December 2022 were divided into phlegm-stasis group(n=150)and non-phlegm-stasis group(n=152)according to TCM syndrome differentiation.General clinical data,total cholesterol(TC),low-density lipoprotein(LDL),fibrino-gen(FIB),hypersensitive C-reactive protein(hs-CRP),homocysteine,(Hcy),uric acid(UA),platelet(PLT),medium/lymphocyte ratio(NRL),mean platelet volume(MPV),LP(a)and other laboratory indices were collected from the two groups.The differences in LP(a)levels between the two groups were compared and analyzed.Correlation between LP(a)and the above influencing factors.Results:There were significant differences in LP(a),TC,Hcy,UA,NRL,smok-ing history,and drinking history between the two groups(P<0.05).In terms of LP(a),Hcy,UA,NRL,smoking history,and drinking history,the levels of the phlegm-stasis group were significantly higher than those of the non-phlegm-stasis group(P<0.05).There were no significant differences in gender,age,LDL,FIB,hs-CRP,PLT,MPV,history of hypertension,and history of diabetes(P>0.05).The LP(a)level was positively correlated with TC,Hcy,and UA in both groups,and the difference was statistically significant(P<0.05).In the phlegm-stasis group,the LP(a)level was more significantly positively correlated with Hcy and UA,and the difference was statistically significant(P<0.01).Conclu-sion:The serum LP(a)level in patients with phlegm-stasis type CI is higher than that in patients without phlegm-stasis type,and is positively correlated with TC,Hcy,and UA,and the positive correlation with Hcy and UA is more significant.The correlation analysis of serum LP(a)level in patients with phlegm-stasis type CI provides a reference for clinical exploration of objective indicators of TCM diagnosis of patients with phlegm-stasis type CI,and also provides a reference for preventing the occurrence of phlegm-stasis type cerebral infarction and controlling risk factors.
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