目的:观察化瘀通络汤对脑小血管病轻度认知障碍的治疗效果.方法:将符合标准的 80 名患者作为研究对象,并以随机数字表的方式分为观察组和对照组各 40 例.2 组病人进行常规内科基础治疗、认知知觉功能训练和针刺治疗,并在配合治疗的同时将化瘀通络汤应用于观察组.4 周后,将评估 2 组患者的临床疗效及安全性,并观察相关量表分数在 2 组治疗前后的变化,选择蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)和简易精神状态量表(Mini-Mental state examination,MMSE)对患者的认知能力施行评测,以及用于测评患者的日常生活自理能力的日常生活能力量表(Activities of daily living,ADL).结果:应用化瘀通络汤的观察组疗效(92.5%)较对照组(70%)提升显著,差别存在统计学意义(P<0.05).MoCA、MMSE和ADL的分值经过治疗后评析,均较治疗前有明显提高,差值达到了显著的程度(P<0.01);2 组的MoCA、MMSE和ADL数值进行组间对比,化瘀通络汤组分值升高明显,症状改善显著(P<0.01).结论:对脑小血管病所致的轻度认知障碍病人,化瘀通络汤的疗效显著,能使病人认知能力及日常生活能力显著提高,它对卒中风险的下调有一定影响,并且不增长药物风险,有临床应用价值.
Clinical Observation of Huayu Tongluo Decoction in the Treatment of Mild Cognitive Impairment Caused by Small Cerebral Vascular Disease
Objective:To observe the therapeutic effect of Huayu Tongluo decoction on mild cognitive impairment in patients with cerebral small vessel disease.Methods:A total of 80 patients who met the criteria were selected as the research subjects and were randomly divided into an observation group and a control group with 40 cases in each group.The two groups of patients received routine basic medical treatment,cognitive perceptual function training and acu-puncture treatment,and Huayu Tongluo decoction was applied to the observation group in conjunction with the treat-ment.After 4 weeks,the clinical efficacy and safety of the two groups of patients were evaluated,and the changes in the scores of relevant scales before and after treatment were observed in the two groups.The Montreal cognitive assessment(MoCA)and the Mini-Mental state examination(MMSE)were selected to evaluate the patients'cognitive ability,and the Activities of daily living(ADL)scale was used to evaluate the patients'daily self-care ability.Results:The efficacy of the observation group(92.5%)using Huayu Tongluo decoction was significantly improved compared with the control group(70%),and the difference was statistically significant(P<0.05).After treatment,the scores of MoCA,MMSE and ADL were evaluated and compared with those before treatment,and the difference reached a significant degree(P<0.01);the MoCA,MMSE and ADL values of the two groups were compared between the two groups.The scores of the Huayu Tongluo decoction group increased significantly,and the symptoms improved significantly(P<0.01).Conclusion:Huayu Tongluo decoction has a significant effect on patients with mild cognitive impairment caused by cerebral small vessel disease,which can significantly improve the patient's cognitive ability and daily living ability.It has a certain effect on the reduction of stroke risk,and does not increase the risk of drugs,and has clinical application value.
Cerebral small vessel diseaseMild cognitive impairmentHuayu Tongluo decoction
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