中医药临床杂志2024,Vol.36Issue(9) :1719-1727.DOI:10.16448/j.cjtcm.2024.0920

青蒿鳖甲汤治疗癌因性发热有效性及安全性分析

The Meta-analysis of the Efficacy and Safety of Qinghao-Biejia Decoction in Treating Cancer-related Fever

张宸 董胡可 张东伟
中医药临床杂志2024,Vol.36Issue(9) :1719-1727.DOI:10.16448/j.cjtcm.2024.0920

青蒿鳖甲汤治疗癌因性发热有效性及安全性分析

The Meta-analysis of the Efficacy and Safety of Qinghao-Biejia Decoction in Treating Cancer-related Fever

张宸 1董胡可 2张东伟3
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作者信息

  • 1. 安徽中医药大学 安徽合肥 230012
  • 2. 安徽医科大学 安徽合肥 230032
  • 3. 安徽中医药大学第一附属医院 安徽合肥 230031
  • 折叠

摘要

目的:系统评价青蒿鳖甲汤(QHBJD)治疗癌性发热的疗效和安全性.方法:计算机检索中国知网等八个大型数据库,搜集关于青蒿鳖甲汤治疗癌性发热的随机对照试验(randomized controlled trial,RCT).在获取资料后进行meta分析.结果:共纳入23个RCT实验,2002例患者,Meta分析结果显示结果显示在有效率方面青蒿鳖甲汤组的退热有效率高于单纯西药组(P<0.05).青蒿鳖甲汤组对于癌性发热的治愈率高于单纯西药组(P<0.05).蒿鳖甲汤组治疗癌性发热不良反应低于单纯西药组(P<0.05).青蒿鳖甲汤组相比较单纯西药组可以更大程度上改善炎症反应,降低白细胞计数(P<0.05).结论:青蒿鳖甲汤对于癌因性发热治疗的有效率治愈率皆高于单纯西药,同时不良反应低于对照组,青蒿鳖甲汤可以显著降低白细胞计数,改善患者炎症状态.

Abstract

Objective:To systematically evaluate the efficacy and safety of Qinghao Biejia Decoction (QHBJD) in the treatment of cancer fever. Methods:Eight large databases including CNKI were searched by computer to collect rand-omized controlled trials (RCTs) on the treatment of cancer fever with Qinghao Biejia Decoction. Meta-analysis was per-formed after obtaining the data. Results:A total of 23 RCT experiments with 2002 patients were included. The meta-analysis results showed that the effective rate of Qinghao Biejia Decoction group was higher than that of the Western medicine group (P<0.05). The cure rate of cancer fever in the Qinghao Biejia Decoction group was higher than that in the Western medicine group (P<0.05). The adverse reactions of the treatment of cancer fever in the Hao Biejia Decoc-tion group were lower than those in the Western medicine group (P<0.05). The Qinghao Biejia Decoction group could improve the inflammatory response and reduce the white blood cell count to a greater extent than the Western medicine group (P<0.05). Conclusion:The effective rate and cure rate of Qinghao Biejia Decoction in the treatment of cancer-related fever are higher than those of Western medicine alone,and the adverse reactions are lower than those of the control group. Qinghao Biejia Decoction can significantly reduce the white blood cell count and improve the inflamma-tory state of patients.

关键词

青蒿鳖甲汤/癌性发热/meta分析/随机对照实验

Key words

Qinghao Biejia Decoction/Cancer-related fever/Meta-analysis/Randomized controlled trial

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出版年

2024
中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
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