Effects of Huangdi Anxiao Capsules on Inflammation of Rats with Kidney-yin Deficiency
Objective:Exploring the effect of Huangdi Anxiao Capsules on inflammation in kidney-yin-deficient diabet-ic rats. Methods:Seventy rats were randomly divided into a blank group,a model group,a low-dose group of Huangdi Anxiao Capsules,a medium-dose group of Huangdi Anxiao Capsules,a high-dose group of Huangdi Anxiao Capsules,a metformin group,and a Traditional Chinese medicine control group.The concentration levels of GLP-1,Leptin,IL-1β,IL-6 and TNF-α were detected by ELISA,and the levels of mRNA and protein expression were detected by RT-qPCR and Western blot. Results:Compared with the blank group,the expression levels of Leptin,IL-1β,IL-6 and TNF-α were significantly increased in serum and pancreatic tissues of rats in the model group,while the level of GLP-1 was decreased. The factors,such as Leptin,IL-1β,IL-6 and TNF-α,were significantly decreased in serum and pancre-atic tissues of the rats in the high dose group of Huangdi Anxiao Capsules compared with the model group,while the level of GLP-1 was increased. Conclusion:Huangdi Anxiao Capsules may exert therapeutic effects by inhibiting the inflammatory state of kidney-yin-deficient diabetic rats.
Huangdi Anxiao CapsulesRats with kidney-yin deficiencyInflammatoryTraditional Chinese medicine
万方数据
维普
