The Therapeutic Effect and Partial Mechanism Exploration of the Combination of Maxing Xiebai San and Western Medicine in the Treatment of Acute Exacerbation of Connective Tissue Disease-related Interstitial Lung Disease
Objective:To explore the effects of Maxing Xiebai powder combined with western medicine on clinical efficacy,lung function,tumor markers and safety in patients with acute exacerbation of connective tissue disease-relat-ed interstitial lung disease,so as to provide a basis for improving the clinical treatment effect of the disease. Methods:A total of 100 patients with acute exacerbation of connective tissue disease-related interstitial lung disease admitted to Anyang Hospital of Traditional Chinese Medicine from February 2022 to February 2023 were divided into 2 groups by random number table method. The control group was treated with western medicine (prednisone acetate tablets+compound cyclophosphamide tablets),and the observation group was treated with Maxing Xiebai powder combined with western medicine. There were 50 cases in each group,and both groups were treated for 6 consecutive months. The two groups were compared in terms of clinical efficacy,lung function (forced expiratory volume in 1 second,forced vital ca-pacity,CO diffusion capacity),tumor markers (carcinoembryonic antigen,neuron-specific enolase,carbohydrate anti-gen 199,carbohydrate antigen 125),serological indicators (interleukin-6,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio) before and after treatment,and adverse reactions during treatment. Results:The effective rate of the observation group was higher than that of the control group. Compared with before treatment,after 6 months of treat-ment,the forced expiratory volume in 1 second,forced vital capacity and CO diffusion capacity of the two groups of pa-tients increased,and the observation group was higher than that of the control group. Compared with before treatment,after 6 months of treatment,the levels of carcinoembryonic antigen,neuron-specific enolase,carbohydrate antigen 199 and carbohydrate antigen 125 of the two groups of patients decreased,and the observation group was lower than that of the control group. Compared with before treatment,after 6 months of treatment,the levels of interleukin-6,neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio of the two groups of patients decreased,and the observation group was lower than that of the control group,and the differences were statistically significant. During the treatment,the incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was not statistically significant. Conclusion:Maxing Xiebai powder combined with western medicine has significant efficacy in the treatment of patients with acute exacerbation of connective tissue disease-related interstitial lung disease,can improve patients' lung function,reduce the body's inflammatory response,and reduce the expression level of tumor markers,and has good safety.
万方数据
维普
