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补肾活血汤联合八珍汤在股骨转子间骨折中的临床应用

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目的:观察中药复方补肾活血汤联合八珍汤在股骨转子间骨折的临床应用;方法:选取符合标准的90例股骨转子间骨折患者,随机数字表分为对照组(45例)和试验组(45例),对照组所有病例均行股骨近端防旋髓内钉(PFNA)内固定术,术后常规预防感染、预防血栓等综合治疗.试验组在对照组的治疗基础上,术后予以口服中药复方.比较2组在围手术期的住院时间、术后视觉疼痛模拟(VAS)评分、髋关节Harris评分、纤维蛋白原、D-二聚体及术后的平均骨折愈合时间、骨密度值、并发症发生率差异.结果:试验组、对照组最终各有41、43例病例纳入研究.试验组在术前以及术后3天随访时与对照组各项指标水平相当(P>0.05),但术后试验组的平均住院时间、骨折愈合时间明显低于对照组(P<0.05).尽管术后最终3月随访时2组的VAS评分无明显差异,但术后1周、1月随访时试验组明显低于对照组(P<0.05),且术后1周、1月、3月试验组的Harris评分明显均优于对照组(P<0.05).在实验室指标来看,术后1周、1月试验组的D-二聚体水平及纤维蛋白原水平是明显低于对照组(P<0.05),在术后6月随访时测定的骨密度值水平,试验组也是明显低于对照组(P<0.05).在整体随访过程中,对照组共有12例出现并发症,试验组仅有4例出现并发症,试验组的并发症发生率也是明显低于对照组(P<0.05).结论:在股骨转子间骨折手术治疗过程中,基于骨折辨证理论,术后予以中药补肾活血汤联合八珍汤口服,可以缩短住院时间,有效的缓解患者围手术期的疼痛,更好的重塑患者的髋关节功能,改善患者术后的高凝状态,降低术后的并发症发生情况,延缓骨质疏松的进一步加重,进一步促进骨折的愈合.
The Clinical Application of Bushen Huoxue Decotion and Bazhen Decotion in Intertrochanteric Femoral Fractures
Objective:To observe the clinical application of Chinese herbal compound Bushen Huoxue Decoction combined with Bazhen Decoction in intertrochanteric fracture of the femur. Methods:A total of 90 patients with inter-trochanteric fracture of the femur who met the criteria were selected and divided into a control group (45 cases) and an experimental group (45 cases) according to a random number table. All cases in the control group underwent proximal femoral anti-rotation intramedullary nail (PFNA) internal fixation,and received routine comprehensive treatment such as postoperative prevention of infection and thrombosis. The experimental group was given oral Chinese herbal com-pound after surgery on the basis of the treatment of the observation group. The perioperative hospital stay,postopera-tive visual analog pain (VAS) score,hip Harris score,fibrinogen,D-dimer,and postoperative average fracture healing time,bone mineral density,and complication rate were compared between the two groups. Results:A total of 41 cases in the experimental group and 43 cases in the control group were included in the study. The levels of various indica-tors in the experimental group before surgery and at the 3-day follow-up after surgery were comparable to those in the control group (P>0.05),but the average hospital stay and fracture healing time in the experimental group were signifi-cantly lower than those in the control group (P<0.05). Although there was no significant difference in the VAS scores between the two groups at the final 3-month follow-up after surgery,the VAS scores in the experimental group were significantly lower than those in the control group at the 1-week and 1-month follow-up after surgery (P<0.05),and the Harris scores in the experimental group at 1-week,1-month,and 3-month follow-up after surgery were significantly better than those in the control group (P<0.05). In terms of laboratory indicators,the D-dimer and fibrinogen levels in the experimental group at 1-week and 1-month after surgery were significantly lower than those in the control group (P<0.05),and the bone density values measured at the 6-month follow-up after surgery were also significantly lower in the experimental group than in the control group (P<0.05). During the overall follow-up,a total of 12 cases in the control group had complications,while only 4 cases in the experimental group had complications,and the incidence of complications in the experimental group was also significantly lower than that in the control group (P<0.05). Conclu-sion:In the surgical treatment of intertrochanteric fracture,based on the fracture differentiation theory,oral adminis-tration of Chinese medicine Bushen Huoxue Decoction combined with Bazhen Decoction after surgery can shorten the hospital stay,effectively relieve the patient's perioperative pain,better reshape the patient's hip joint function,im-prove the patient's postoperative hypercoagulable state,reduce the incidence of postoperative complications,delay the further aggravation of osteoporosis,and further promote fracture healing.

Bushen Huoxue DecoctionBazhen Decoctionintertrochanteric fracturePFNA surgery

谭成成、杨东林、潘学啟、金加奎

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安徽省霍邱县中医院 安徽霍邱 237400

补肾活血汤 八珍汤 股骨转子间骨折 PFNA术

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(9)