首页|基于"阳化气,阴成形"理论与自噬的相关性探讨冠心病的中医药干预

基于"阳化气,阴成形"理论与自噬的相关性探讨冠心病的中医药干预

扫码查看
《素问·阴阳应象大论篇》"阳化气,阴成形"理论蕴含深刻的生命观、恒动观、疾病观,可以用于指导冠心病的诊治.自噬通过分解细胞内的有机物质,提供细胞所需的能量和营养物质,在维持细胞内环境稳态中起着重要作用.目前研究发现自噬在冠心病发展过程中起重要作用,且与中医"阳化气,阴成形"理论密切相关.冠心病自噬状态多因"阳化气,阴成形"功能失司,痰瘀堆积,痹阻心脉,病属为本虚标实.中药复方和中药单体均能调控自噬,中药复方可分为益气活血类、益气化痰类、化痰祛瘀类,主要通过促进或抑制自噬,稳定斑块,改善血管微环境,从而延缓冠心病进展.文章从"阳化气,阴成形"角度探讨自噬微环境与冠心病的相关性,挖掘中医药防治冠心病的潜在新靶点,具有重大的临床意义和广泛的应用价值.
Exploration of Traditional Chinese Medicine Intervention in Coronary Heart Disease based on the Correlation between the Theory of"Yang Transforming Qi,Yin Forming"and Autophagy
The theory of"Yang-transforming Qi,Yin-forming"contains profound views of life,constant movement and disease,which can be used to guide the diagnosis and treatment of coronary heart disease.Autophagy,as a new ap-optotic process,plays a role in energy maintenance and nutrient recycling by breaking down the organic matter in cells to provide them with the energy and nutrients they need,it plays an important role in maintaining the homeostasis of the intracellular environment.At present,it is found that Autophagy plays an important role in the development of coro-nary heart disease and is closely related to the theory of"Yang-transforming Qi,Yin-forming"in TCM.The Autophagy state of coronary heart disease is mainly due to the function of"Yang-transforming Qi,Yin-forming",accumulation of Phlegm and blood stasis,obstruction of the heart vessels.Traditional Chinese medicine(TCM)can regulate Autophagy,which can be divided into three groups:invigorating Qi and promoting blood circulation,invigorating Qi and resolv-ing phlegm,resolving phlegm and removing blood stasis,therefore,it can delay the progress of coronary heart disease.This paper discusses the relationship between Autophagy micro environment and coronary heart disease(CHD)from the angle of"Yang-transforming Qi,Yin-forming",and excavates the potential new targets of TCM in the prevention and treatment of CHD,which has great clinical significance and extensive application value.

Coronary heart diseaseYang transforming QiYin formingAutophagyChinese Medicine

卢圣花、刘建和、戴思思

展开 >

湖南中医药大学第一中医临床学院 湖南长沙 410007

冠心病 阳化气 阴成形 自噬 中医药

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(10)