摘要
目的:观察芪术扶正饮联合甲地孕酮治疗癌性恶病质的疗效及作用机制.方法:收集癌性恶病质脾肾两虚证患者208例,按照1∶1分为观察组和对照组.对照组给予醋酸甲地孕酮分散片160mg 1次/d 口服治疗,1月为1个疗程,连续服用2个疗程.观察组在对照组基础上给予芪术扶正饮治疗,1日1副,1月为1个疗程,连续服用2个疗程.比较2组患者治疗前后体力状况ECOG评分、中医症候积分、营养评估PG-SGA评分以及血浆白蛋白(ALB)水平和白细胞介素-6(IL-6)水平检验指标的变化以及治疗后不良事件.结果:2组治疗后患者体力状况ECOG评分、中医症候积分、营养评估PG-SGA评分、ALB水平和IL-6水平均优于治疗前,且观察组疗效显著优于对照组,差异有统计学意义.2组患者治疗后常见的不良事件发生率相近.结论:芪术扶正饮能够安全、有效的改善癌性恶病质.
Abstract
Objective:To observe the efficacy and mechanism of Qishu Fuzheng Yin combined with megestrol ac-etate in the treatment of cancer cachexia.Methods:A total of 208 patients with cancer cachexia with spleen and kidney deficiency were enrolled and divided into an observation group and a control group at a ratio of 1∶1.The control group was treated with megestrol acetate dispersible tablets 160 mg orally once a day,one month as a course of treatment,and continued for 2 courses.The observation group was treated with Qishu Fuzheng Yin on the basis of the control group,one pair per day,one month as a course of treatment,and continued for 2 courses.The ECOG score of physical condi-tion,TCM symptom score,nutritional assessment PG-SGA score,changes in plasma albumin(ALB)level and IL-6 lev-el test indicators before and after treatment,and adverse events after treatment were compared between the two groups.Results:After treatment,the ECOG score,TCM symptom score,nutritional assessment PG-SGA score,plasma albumin(ALB)level and IL-6 level of the two groups of patients were better than before treatment,and the efficacy of the ob-servation group was significantly better than that of the control group,with statistically significant differences.The in-cidence of common adverse events after treatment in the two groups of patients was similar.Conclusion:Qishu Fuzheng Decoction can safely and effectively improve cancer cachexia.
维普
万方数据