Clinical Observation of Aidi Injection Combined with Endocrine Therapy for Metastatic Hormone Sensitive Prostate Cancer
Objective:To observe the clinical efficacy of Aidi injection combined with endocrine therapy for metastatic hormone-sensitive prostate cancer(mHSPC).Methods:A total of 51 patients with mHSPC were randomly divided into a study group(n=26)and a control group(n=25).Both groups received uninterrupted androgen deprivation therapy(ADT).The study group was given Aidi injection,with 14 days as one course of treatment,for a total of 3 courses.The serum to-tal prostate-specific antigen(tPSA)level,TCM symptom score,visual analogue scale(VAS),European Organization for Research and Treatment of Cancer(EORTC QLQ-C30)score,International Prostate Symptom Score(IPSS),and the in-cidence of adverse reactions were compared between the two groups.Results:At the end of observation,the serum tPSA level of the study group was(0.666±1.359)mmol/L,which was lower than that of the control group(1.176±1.451)mmol/L;the TCM symptom score of the study group was(1.62±1.47)points,which was lower than that of the control group(3.32±1.86)points;the VAS score of the study group was(0.81±1.17)points,which was significantly lower than that of the control group(1.76±1.23)points;the QLQ-C30 score of the study group(87.92±6.09)points was higher than that of the control group(78.88±6.69)points;the IPSS score of the study group was(9.08±2.54)points,which was lower than that of the control group(13.72±3.36)points;the total incidence of adverse reactions(15.38％)and anemia(7.69％)in the study group were lower than those in the control group(total incidence 44％,anemia 32％),the differences were statisti-cally significant.There was no statistically significant difference in the incidence of adverse reactions such as hot flashes,breast development and fatigue.Conclusion:Compared with endocrine therapy alone,Aidi injection combined with endo-crine therapy can improve clinical efficacy,relieve pain,improve symptoms,improve quality of life,and reduce the occur-rence of adverse reactions,which is worthy of clinical promotion and application.
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