To Discuss the Pathogenesis Markers of'Spleen Deficiency'base on the Role of KCNQ1-KCNE2 in the Occurrence of Gastric Cancer
In recent years,the incidence of gastric cancer has gradually become younger.With the advancement of screening methods,the early screening rate of gastric cancer has also increased year by year.The mechanism of gas-tric cancer occurrence and development is complex and diverse.The most classic cognition is the evolution model of"normal gastric mucosa-chronic superficial gastritis-chronic atrophic gastritis-intestinal metaplasia,dysplasia-gastric cancer".The organic combination of traditional Chinese medicine syndrome differentiation and treatment with Western medicine surgery,radiotherapy and chemotherapy,and targeted immunotherapy can effectively prolong the patient's survival and improve the quality of life.Therefore,exploring the pathogenesis of gastric cancer from the perspective of integrated traditional Chinese and Western medicine has a certain reference value for the clinical treatment of gastric cancer.At present,some scholars regard cancer as a channel disease and believe that abnormal ion channel function or expression is a related mechanism of cancer pathogenesis.Among them,the low expression and deficiency of KCNQ1-KCNE2 potassium channel heteromers(KCNQ1:Potassium Voltage-Gated Channel Subfamily Q Member 1;KCNE2:Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 2)can promote the occurrence and development of gastric cancer to a certain extent.The mechanism is related to the fact that KCNE2 deficiency leads to changes in the position of KCNQ1 on parietal cells,changes in the direction of potassium ion flow,inhibition of gastric acid production leading to functional atrophy,and KCNE2 deficiency leads to upregulation of cyclin D1 expression,which is similar to the classic evolution pattern.From the perspective of TCM etiology and pathogenesis,the occurrence and development of gastric cancer are generally inseparable from"spleen deficiency".The pathogenesis and symptom manifestations of"spleen deficiency"accumulated over time are similar to a series of manifestations of gastric cancer induced by ab-normal KCNQ1-KCNE2 heteromers.Modern medical interpretation of"spleen deficiency"is related to reduced gastric acid secretion,CyclinD1,and some ion channels.Therefore,this article adopts the method of analogy,aiming to explore the mechanism of action of KCNQ1-KCNE2 heteromers in gastric cancer from the perspective of etiology and patho-genesis,with functional atrophy and Cyclin D1 as the entry point,and on this basis,try to explore the modern medical marker basis of the pathogenesis of"spleen deficiency"in gastric cancer.
Spleen deficiencyGastric cancerPotassium ion channel proteinKCNQ1KCNE2
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