首页|基于"脑肠轴"理论探讨灸法治疗功能性消化不良的作用机制

基于"脑肠轴"理论探讨灸法治疗功能性消化不良的作用机制

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功能性消化不良(FD)是临床常见的消化系统疾病,其病因与发病机制尚未完全明确.目前,普遍认为脑肠轴功能异常是FD发病的重要机制,贯穿疾病始终.脑-肠轴是胃肠道和大脑之间的双向通路,通过神经传导、内分泌免疫因子的释放等方式调节;脑肠轴失衡同样参与其他发病机制作用的过程.中医理论认为脑与胃肠之间同样存在着广泛的联系,其生理病理密切相关.文章论述了灸法通过脑肠轴对脑肠肽、HPA轴及肠道菌群等产生的影响,探讨灸法对FD的调节作用及其可能机制,为灸法治疗FD的研究提供参考.
To Explore the Mechanism of Moxibustion in the Treatment of Functional Dyspepsia based on the Theory of"Brain-gut Axis"
Functional dyspepsia(FD)is a common digestive system disease in clinic,and its etiology and patho-genesis are not yet fully understood.At present,it is generally believed that abnormal brain-gut axis function is an important mechanism of FD,which runs through the disease.The brain-gut axis is a bidirectional pathway between the gastrointestinal tract and the brain,which is regulated by nerve conduction,the release of endocrine immune factors,etc.;imbalance of the brain-gut axis is also involved in the process of other pathogenesis.Traditional Chinese medicine theory believes that there is also a wide range of connections between the brain and the gastrointestinal tract,and their physiology and pathology are closely related.This paper discusses the effects of moxibustion on brain-gut peptides,HPA axis and intestinal flora through the brain-gut axis,explores the regulatory effect of moxibustion on FD and its possible mechanism,and provides a reference for the study of moxibustion treatment of FD.

Functional dyspepsiaMoxibustionBrain-gut axisBrain-gut peptidesHPA axisIntestinal flora

韩超、张建英、王秀、徐聪

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山东中医药大学 山东 济南 250013

山东中医药大学附属医院 山东 济南 250011

功能性消化不良 灸法 脑肠轴 脑肠肽 HPA轴 肠道菌群

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(11)