Clinical Observation of Modified Qingjin Huatan Decoction Jiawei Combined with Tanreqing Injection in the Treatment of Patients with Pulmonary Lymphangitic Carcinomatosis
Objective:To observe the clinical efficacy of Qingjin Huatan Decoction plus Tanreqing Injection in the treatment of patients with lung cancer lymphangitis.Methods:Thirty patients diagnosed with lung cancer lymphangi-tis and diagnosed with phlegm-heat obstructing the lung according to TCM differentiation who met the criteria were randomly divided into an observation group and a control group.The control group received symptomatic supportive treatment of Western medicine,while the observation group was given Qingjin Huatan Decoction plus Tanreqing Injec-tion on the basis of symptomatic supportive treatment of Western medicine.The treatment course of both groups was 14 days.The clinical manifestations,total score of TCM syndrome,C-reactive protein(CRP),procalcitonin(PCT),vas-cular endothelial growth factor(VEGF)levels,immunoglobulins(IgA,IgG,IgM),T lymphocyte subsets(CD3+,CD4+),blood oxygen partial pressure(PO2),blood carbon dioxide partial pressure(PaCO2),carcinoembryonic antigen(CEA),carbohydrate antigen CA125(CA125),cytokeratin 19 fragment(CYFRA21-1)and other tumor markers were compared between the two groups before and after treatment,and the occurrence of adverse reactions in the two groups during treatment was observed.Results:After treatment,the clinical symptoms such as shortness of breath and dyspnea,lung diffusion function and TCM symptom scores such as cough,wheezing,fever,thirst,flushing and constipation in the observation group were significantly improved,and were significantly better than those in the control group(P<0.05).After treatment,the levels of VEGF,CEA,CA125,CYFRA21-1,CRP,PCT,IgA,IgG,IgM,CD3+and CD4+in the observation group were all reduced,and the reduction in the observation group was more significant than that in the control group(P<0.05).After treatment,PO2 of the two groups of patients increased,and the increase in the observa-tion group was more significant than that in the control group(P<0.05).After treatment,PaCO2 of the observation group was reduced compared with that before treatment,and was lower than that of the control group(P<0.05).There was no significant difference in PaCO2 of the control group after treatment compared with that before treatment(P>0.05).Both groups of patients had a period of treatment.Adverse reactions such as bone marrow suppression,skin reaction,diges-tive tract reaction,liver and kidney dysfunction,etc.were relieved after treatment.There was no significant difference between the two groups(P>0.05).Conclusion:Qingjin Huatan Decoction plus Tanreqing Injection has significant clini-cal efficacy in the treatment of patients with lung cancer lymphangitis,which can improve the respiratory function of patients,reduce inflammatory response,enhance anti-tumor immune function,effectively improve the quality of life of patients,and improve the long-term prognosis to a certain extent.
Lung cancer lymphangitisTanreqing InjectionQingjin Huatan DecoctionPhlegm-heat blocking the lungs