Clinical Study on Improving the Side Effects of Chemotherapy in Malignant Tumors with Fuzheng Shengbai Cream
Objective:To observe the effect of Fuzheng Shengbai ointment on the side effects of cisplatin chemo-therapy.Methods:A prospective study method was used to screen 60 patients with malignant tumors who were treated with cisplatin chemotherapy in the Department of Oncology of Yunyang County Traditional Chinese Medicine Hospital in Chongqing.They were randomly divided into a control group(cisplatin chemotherapy only without Chinese medicine)and an experimental group(continuous oral administration of Fuzheng Shengbai ointment during cisplatin chemothera-py).The KPS scores and chemotherapy-related symptom scores of the two groups of patients during the treatment cycle were recorded,and the SF-36 life scale scores of the two groups of patients before and after treatment were evalu-ated.The blood routine tests of the two groups of patients during the treatment were collected,and the expression of apoptosis-related proteins in the peripheral blood of the two groups of patients before and after treatment was detected.Results:A total of 56 patients were included in the statistics,including 27 in the control group and 29 in the experi-mental group.In terms of clinical efficacy,compared with the control group,the KPS scores,chemotherapy-related symptom scores,SF-36 quality of life scores and immunosuppression of the experimental group were significantly im-proved(P<0.05).In terms of the expression of apoptosis-related proteins in peripheral blood,the expression levels of Caspase-3 and Caspase-9 in the experimental group were lower than those in the control group(P<0.05).Conclusion:Fuzheng Shengbai Paste can improve cisplatin chemotherapy-related damage and reduce the immunosuppressive effect of cisplatin.Its mechanism may be related to reducing the apoptosis pathway of cisplatin on blood nucleated cells.
万方数据
维普
