Observation on the Effect of Xiaozhong Sanjie Decoction Combined with TX Chemotherapy in the Treatment of Advanced Triple Negative Breast Cancer
Objective:To analyze the efficacy of Xiaozhong Sanjie Decoction assisted by docetaxel combined with capecitabine(TX)chemotherapy in the treatment of advanced triple-negative breast cancer(TNBC).Methods:A retro-spective analysis was performed on 86 patients with advanced TNBC admitted to the First People's Hospital of Nan-yang City,Henan Province from January 2021 to January 2024.The patients were divided into a control group and an observation group,with 43 cases in each group,according to different treatment regimens.The control group was treated with TX chemotherapy,and the observation group was treated with Xiaozhong Sanjie Decoction+TX chemotherapy.The clinical efficacy,TCM syndrome scores,tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigens(CA125,CA153)],Karnofsky performance status(KPS)score,and toxic and side effects were compared between the two groups.Results:The clinical objective remission rate of the observation group was 58.14%(25/43),which was higher than that of the control group 34.88%(15/43)(P<0.05).After treatment,the TCM syndrome score(dizziness,breast mass,weight loss,poor appetite,shortness of breath and fatigue)of the observation group was lower than that of the control group(P<0.05).After treatment,the CEA,CA125,and CA153 of the observation group were lower than those of the control group,and the KPS score was higher than that of the control group(P<0.05).There was no significant dif-ference in the incidence of leukopenia,nausea and vomiting,liver and kidney damage,alopecia,and thrombocytopenia between the two groups(P>0.05).Conclusion:Xiaozhong Sanjie Decoction combined with TX chemotherapy regimen has significant efficacy in the treatment of advanced TNBC,can alleviate the symptoms of patients,reduce the expres-sion of tumor markers,improve the physical condition of patients,and has good safety.
Advanced triple-negative breast cancerXiaozhong Sanjie DecoctionTX chemotherapy regimenToxic and side effectsTCM syndrome score
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