Wilson's disease(WD)is an autosomal recessive genetic disease caused by ATP7B gene mutation.Its main pathogenesis is the disorder of ceruloplasmin synthesis,copper cannot be excreted from bile,and copper is de-posited in various organs,resulting in pathological changes.Insomnia is a common non-motor symptom of WD.Tra-ditional Chinese medicine believes that insomnia belongs to the category of"insomnia",which is often related to the heart,liver,and kidney.Heart yang deficiency,kidney water deficiency,and liver depression are all causes of insom-nia.The"liver-heart harmony"theory was first proposed and applied to"double heart disease".In recent years,it has been used as a treatment idea for insomnia.Based on traditional Chinese medicine theory and modern clinical research,this article discusses the basis and clinical application points of the"liver-heart harmony"theory for the diagnosis and treatment of WD insomnia,and provides new ideas and methods for the diagnosis and treatment of WD insomnia in tra-ditional Chinese medicine.
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