Explore the Medication Rule of Chinese Medicine for Rheumatoid Arthritis based on Data Mining Method
Objective:To explore the clinical syndrome and prescription rules of Chinese medicine in the treatment of rheumatoid arthritis(RA)based on R language data mining.Methods:The clinical research literature on Chinese medicine treatment of RA from the establishment of CNKI,Wanfang and VIP databases to October 2023 was retrieved.Frequency analysis,correlation analysis,association rule analysis,cluster analysis and other methods were used for statistical analysis.Results:Finally,344 prescriptions were included.The disease has 8 syndromes,including wind-cold arthralgia syndrome,damp-heat arthralgia syndrome,liver-kidney deficiency syndrome,etc.A total of 251 single Chinese medicines were used,with a total of 4066 times.The top 5 in terms of frequency of use were licorice,angelica,cinnamon twig,white peony root and astragalus.There were 30 Chinese medicines with a frequency of use>50 times,involving 13 effects,mainly dispersing wind-cold drugs,blood-tonifying drugs,qi-tonifying drugs and wind-cold-dampness-dispelling drugs.Correlation analysis obtained 20 drug combinations with high correlation coefficients,and association rule analysis obtained drug combinations with Duhuo as the core,such as Qianghuo → Duhuo and Qianghuo → Duhuo,Guizhi.Cluster analysis obtained 2 new prescription combinations,which can be used for syn-drome differentiation and treatment according to different syndrome types.Conclusion:This study clarified the char-acteristics of TCM treatment of RA,which is mainly to nourish qi and blood,nourish the liver and kidney,and to dispel wind,dampness and relieve pain,which can provide reference and reference for TCM medication of RA.
万方数据
维普
