首页|基于"金水相生"理论探讨补肾固金膏对慢性阻塞性肺疾病稳定期的影响

基于"金水相生"理论探讨补肾固金膏对慢性阻塞性肺疾病稳定期的影响

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目的:基于"金水相生"理论探讨补肾固金膏对慢性阻塞性肺疾病简称慢阻肺(COPD)稳定期患者中医证候积分、CAT评分、炎症因子、肺功能的影响.方法:选取 60 例COPD稳定期患者,按随机数字表法分为对照组和治疗组各 30 例,对照组给予常规治疗,治疗组加用补肾固金膏,对 2 组患者用药前后中医证候积分、CAT评分、血清炎症因子白细胞介素-8(IL-8)、白细胞介素-17(IL-17)、白细胞介素-33(IL-33)水平及肺功能进行比较.结果:①治疗 2 月后,2 组患者的中医证候积分和CAT评分均较用药前明显改善(P<0.05),且治疗组改善更明显(P<0.05).②2 组患者血清IL-8、IL-17、IL-33 水平均较用药前明显降低(P<0.01),且治疗组更显著(P<0.05).③治疗 2 月后,2 组患者的肺功能指标第 1 秒用力呼气容积及其与用力肺活量的比值(FEV1/FVC)较用药前有所升高(P<0.01),且治疗组升高幅度优于对照组(P<0.05).结论:补肾固金膏可降低COPD(稳定期)患者的中医证候积分、CAT 评分及血清炎症因子水平,提高患者肺功能,加速患者机体稳态的恢复,提高患者生活质量.
Exploring the Effect of Bushen Gujin Ointment on the Stable Phase of Chronic Obstructive Pulmonary Disease based on the Theory of"Mutual Growth of Gold and Water"
Objective:To explore the effect of Bushen Gujin Paste on TCM syndrome score,CAT score,inflammatory factors and lung function in patients with stable chronic obstructive pulmonary disease(COPD)based on the theory of"gold and water m2148utual generation".Methods:A total of 60 patients with stable COPD were selected and divided into a control group and a treatment group according to the random number table method,30 cases in each group.The control group was given conventional treatment,and the treatment group was given Bushen Gujin Paste.The TCM syn-drome score,CAT score,serum inflammatory factors interleukin-8(IL-8),interleukin-17(IL-17),interleukin-33(IL-33)levels and lung function of the two groups were compared before and after medication.Results:① After 2 months of treatment,the TCM syndrome score and CAT score of the two groups were significantly improved compared with those before medication(P<0.05),and the improvement in the treatment group was more obvious(P<0.05).② The serum IL-8,IL-17,and IL-33 levels of the two groups of patients were significantly lower than those before medication(P<0.01),and the treatment group was more significant(P<0.05).③ After 2 months of treatment,the lung function indexes of the two groups of patients,including the forced expiratory volume in 1 second and its ratio to forced vital capacity(FEV1/FVC),increased compared with those before medication(P<0.01),and the increase in the treatment group was bet-ter than that in the control group(P<0.05).Conclusion:Bushen Gujin Paste can reduce the TCM syndrome score,CAT score and serum inflammatory factor levels of patients with COPD(stable phase),improve the lung function of patients,accelerate the recovery of the body's homeostasis,and improve the quality of life of patients.

Bushen Gujin PasteChronic obstructive pulmonary diseaseMutual generation of gold and waterIn-terleukin

郝庆伟、程玉峰、夏奔

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安徽省亳州市中医院 安徽亳州 236800

补肾固金膏 慢性阻塞性肺病 金水相生 白介素

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(12)