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肝胆管结石术后柴胡疏肝散治疗临床观察

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目的:观察柴胡疏肝散治疗肝胆管结石术后的临床疗效.方法:选取 63 例确诊为肝胆管结石的患者,行腹腔镜或开腹肝胆管结石手术,术后随机分组,其中对照组 32 例,治疗组 31 例.对照组行腹腔镜或开腹手术治疗,术后予以抗感染、补液等对症治疗;治疗组在此基础上加用柴胡疏肝散治疗.分别观察 2 组治疗前后的症状体征评分、术后机体功能恢复、肝功能、血清胆汁生化、炎症反应以及结石复发率.结果:治疗后,2 组在症状体征评分、术后机体功能恢复上无显著差异.术后 7d,2 组ALT、AST、GGT、AKP和ALB有显著差异.术后 3d,2 组TBA和TB有显著差异(P<0.05);术后 7d,2 组TBA、TB、CB和UCB有显著差异.术后 3d,2 组CRP比较有显著差异;术后 7d,2 组CRP、IL-6、PLT、WBC和NEUT%比较有显著差异.治疗组在 1 年和 2 年的结石复发率明显低于对照组,具有显著差异.结论:柴胡疏肝散发挥传统中医疏肝利胆优势,对肝胆管结石术后具有较好的临床疗效.
Clinical Observation of Treating Hepatolithiasis with Bupleurum Shugan Powder
AIM:To observe the clinical effect of Bupleurum Shugan powder on postoperative hepatolithiasis.METHODS:Sixty-three patients diagnosed with hepatolithiasis were selected for laparoscopic or open hepatolithiasis surgery,and were randomly assigned after surgery,including 32 cases in the control group and 31 cases in the treat-ment group.The control group was treated with laparoscope or open surgery,after which symptomatic treatment such as anti-infection and fluid rehydration was given.The treatment group was additionally treated with bupleurum Shugan powder.The scores of symptoms and signs,postoperative body function recovery,liver function,serum bile biochem-istry,inflammatory response and stone recurrence rate of the two groups were observed respectively.RESULTS:After treatment,there were no significant differences in the scores of symptoms and signs and the recovery of body function between the two groups(P>0.05).At 7 days after operation,ALT,AST,GGT,AKP and ALB were significantly dif-ferent between the two groups(P<0.05).At 3 days after operation,TBA and TB were significantly different between the two groups(P<0.05).There were significant differences in TBA,TB,CB and UCB between the two groups at 7 days after operation(P<0.05).There were significant differences in CRP between the two groups at 3 days after op-eration(P<0.05).There were significant differences in CRP,IL-6,PLT,WBC and NEUT%between the two groups at 7 days after operation(P<0.05).The recurrence rate of stone in the control group at 1 year and 2 years was signifi-cantly lower than that in the control group(P<0.05).CONCLUSION:Bupleurum Shugan Powder plays the advantages of traditional Chinese medicine in soothing liver and gallbladder,and has a good clinical effect on hepatolithiasis.

Bupleurum Shugan powderPostoperative hepatolithiasisClinical observation

李晓泉、黄昱

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北京市健宫医院 北京 100054

柴胡疏肝散 肝胆管结石术后 临床观察

2024

中医药临床杂志
中华中医药学会

中医药临床杂志

影响因子:0.636
ISSN:1672-7134
年,卷(期):2024.36(12)