Clinical Effect of"Essence-filling and Intelligence-enhancing"Acupuncture in Patients with Mild Post-stroke Cognitive Impairment and Its Effect on Serum Homocysteine
Objective To investigate the effect of"essence-filling and intelligence-enhancing"acupuncture on cognitive function and serum homocysteine(Hcy)in patients with mild post-stroke cognitive impairment(PSCI).Methods A total of 116 pa-tients with mild PSCI were randomly divided into control group(58 patients,55 were actually included in the study)and acu-puncture group(58 patients,54 were actually included in the study).The patients in the control group were given basic inter-vention,rehabilitation training,and oral administration of donepezil 5 mg once every night,seven times a week for 8 consecutive weeks,and those in the acupuncture group were given"essence-filling and intelligence-enhancing"acupuncture for 30 minutes each time,once a day and six times a week for 8 weeks,in addition to the treatment in the control group.The two groups were observed and compared in terms of Montreal Cognitive Assessment(MoCA)score,Mini-Mental State Examination(MMSE)score,Barthel Index(BI),and serum Hcy level before and after treatment,and treatment outcome was evaluated based on MMSE score.Results After treatment,both groups had significant increases in MoCA score,MMSE score,and BI(P＜0.05)and a significant reduction in serum Hcy level(P＜0.05),and compared with the control group,the acupuncture group had sig-nificantly greater changes in these indices(P＜0.05).The acupuncture group had a significantly better clinical outcome than the control group(P＜0.05).Conclusion For patients with mild PSCI,"essence-filling and intelligence-enhancing"acupuncture can significantly improve cognitive function and activities of daily living,alleviate the damage of Hcy to brain function,and pro-tect the function of the brain.
StrokeMild cognitive impairmentEssence-filling and intelligence-enhancingDonepezil
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