Press Needling for Cancer-Related Insomnia:A Systematic Review and Meta-analysis
Objective To systematically evaluate the efficacy and safety of press needling in the treatment of cancer-related in-somnia (CRI).Methods We retrieved randomized controlled trials using press needles to treat CRI from China National Knowledge Infrastructure,Wanfang Data,VIP,Chinese Biomedical Literature Database,PubMed,Embase,and the Cochrane Library between database establishment and December 2023.According to the inclusion and exclusion criteria,two evaluators selected literature and extracted data.RevMan 5.3.0 software was used for data integration and analysis.Results Six articles were finally included,involving a total of 500 patients.The meta-analysis results showed that compared with the control group,press needling significantly reduced the total score of the Pittsburgh Sleep Quality Index [mean difference (MD)=-2.31,95% confidence interval (CI)(-2.84,-1.78),P<0.00001].At the same time,the treatment group had significantly better effects than the control group on sleep latency,sleep quality,sleep duration,sleep disorders,sleep efficien-cy,and daytime function.The press needling group was also superior with regard to the overall response rate [risk ratio=0.38,95% CI(0.26,0.57),P<0.00001].At medium frequencies of 1-3 times per day,prolonging the course of press nee-dling treatment could significantly improve the therapeutic effect[12 days:MD=-2.17,95% CI(-3.75,-0.59);28 days:MD=-2.41,95% CI(-3.15,-1.66)].When the treatment lasted for 15 days or longer,the therapeutic outcome was sig-nificantly better with medium-frequency stimulation (1-3 times per day)than with low-frequency stimulation (<1 time per day)[medium frequency:MD=-2.41,95% CI(-3.15,-1.66);low frequency:MD=-1.50,95% CI(-3.38,0.38)].In terms of safety,two trials reported slight adverse reactions,one reported unknown adverse reactions,and the others reported none.Conclusion Press needling is a safe and effective treatment for improving the sleep of patients with CRI,especially for sleep quality.