Clinical Effect of Xuefu Zhuyu Decoction in Prevention and Treatment of Acute Radiation-induced Esophagitis Caused by Concurrent Chemoradiotherapy for Esophageal Cancer
Objective To investigate the clinical effect of Xuefu Zhuyu Decoction in the prevention and treatment of acute radia-tion-induced esophagitis (ARIE)caused by concurrent chemoradiotherapy for esophageal cancer.Methods A total of 86 pa-tients with locally advanced esophageal cancer who underwent concurrent chemoradiotherapy were enrolled,and according to the presence or absence of intervention with Xuefu Zhuyu Decoction,they were divided into treatment group and control group,with 43 patients in each group.The two groups were compared in terms of clinical outcome,the cumulative incidence rate of different grades of ARIE,the remission of TCM syndrome,performance status score,immune and inflammatory indicators[interleukin-4 (IL-4),tumor necrosis factor-α(TNF-α),interferon gamma (IFN-γ),CD4+/CD8+,and Th1/Th2],and adverse events. Results There was no significant difference in clinical outcome between the two groups (P>0.05).The treatment group had a lower cu-mulative incidence rate of grade Ⅰ-Ⅲ ARIE than the control group (P<0.05).Both groups had a significant reduction in TCM syndrome score after treatment (P<0.05),but there was no significant difference in TCM syndrome score between the two groups after treatment (P>0.05).After treatment,both groups had a significant reduction in ECOG score (P<0.05)and a significant increase in KPS score (P<0.05),and compared with the control group,the treatment group had a significantly greater increase in KPS score and a significantly greater reduction in ECOG score (P<0.05).After treatment,both groups had significant reductions in IL-4,TNF-α,IFN-γ,and Th1/Th2 and a significant increase in CD4+/CD8+percentage (P<0.05),and compared with the control group,the treatment group had significant-ly greater reductions in IL-4,IFN-γ,TNF-α,Th1/Th2 and a significantly increase in CD4+/CD8+(P<0.05).There was no significant difference in the incidence rate of adverse events between the two groups (P>0.05). Conclusion Xuefu Zhuyu Decoction can prevent the progression of grade Ⅰ-Ⅲ ARIE to grade Ⅳ ARIE,alleviate clinical symptoms,and restore immunity of the body during radiotherapy for esophageal cancer,thereby improving the performance status and quality of life of patients.
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维普
