Research progress on improving the production and catalytic performance of microbial keratinase
Keratinase is a kind of broad-spectrum protease capable of hydrolyzing insoluble keratin waste,and has good application prospects in fields such as feed,fertilizer,medical treatment,leather making,and detergent.However,low yield,low activity,and poor stability are the main problems limiting the application of natural keratinase.This re-view focuses on recent progress in the strategies to improve the production and catalytic performance of keratinase,includ-ing searching for new keratinase resources,modifying natural hosts,heterologous expression,optimizing fermentation conditions,and modifying keratinase through random mutations and(semi)rational design.By utilizing one or more of the above strategies,it is expected to increase the yield and catalytic performance of keratinase,shorten production time,reduce production costs,and promote the application of keratinase in various fields.
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