Biotransformation of Glycyrrhizic acid by UV mutated Aspergillus niger
Glycyrrhizic acid(GL)is the main component of liquorice root and has obvious pharmaceutical functions. However,its physiological function and transport ability in biosmass was limited due to its structur-al characteristic. The molecular structure of GL can be changed by cleaving one of molecular glucuronide through biological transformation method resulting in the improved polarity. Moreover,the transformed prod-uct monoglucurony-glycyrrhetinic acid has more pharmacological function as well. In this paper,the ability of biotransformation glycyrrhizin by Aspergillus niger were improved by UV mutation. The mutation time of par-ent Aspergillus niger strain was optimized by the fatality curve. Then after screening,re-screening and fermen-tation,the mutated Aspergillus niger which has more bioactivity to transform the glycyrrhizic acid were select-ed. The transformation of glycyrrhizic acid was 6.5 times more than the parent Aspergillus niger.
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万方数据
维普
