Relationship between high-risk human papilloma virus infection and clinical characteristics,immunohistochemical indicators and prognosis of cervical cancer patients
Objective To investigate the relationship between high-risk human papilloma virus(HR-HPV)infection and clinical characteristics,immunohistochemical indicators and prognosis of cervical cancer patients.Method A total of 120 patients with cervical cancer were selected,including 40 patients with HR-HPV negative and 80 patients with HR-HPV positive.The clinical characteristics,immunohistochemical indicators(p16,Ki-67 and p53)and prognosis of the pa-tients with HR-HPV positive and negative were compared.Result There were significant differences for the age,patho-logical type,lymph node metastasis and differentiation degree between HR-HPV negative patients and HR-HPV positive patients(P<0.05).The positive rates of p16 and Ki-67 and 5-year survival rate in HR-HPV negative patients were lower than those in HR-HPV positive patients,and the differences were statistically significant(P<0.05).Conclusion Com-pared with HR-HPV positive cervical cancer patients,HR-HPV negative cervical cancer patients have lower age of onset,higher proportion of adenocarcinoma,higher risk of lymph node metastasis,lower degree of differentiation,lower posi-tive rates of p16 and Ki-67,and worse prognosis.
high-risk human papilloma viruscervical cancerclinical characteristicimmunohistochemical indica-torprognosis
万方数据
维普
