Efficacy and safety of intensity-modulated radiotherapy with different dose escalation methods in the treatment of cervical cancer patients with pelvic and abdominal lymph node metastasis
Objective To explore the efficacy and safety of intensity-modulated radiotherapy with different dose esca-lation methods in the treatment of cervical cancer patients with pelvic and abdominal lymph node metastasis.Method A total of 82 cervical cancer patients with pelvic and abdominal lymph node metastasis were divided into control group(n= 41,received late course dose escalation intensity-modulated radiotherapy)and study group(n=41,received synchronous dose escalation intensity-modulated radiotherapy)according to different dose escalation methods.The clinical efficacy,ra-diation dose to organs at risk,treatment time,and occurrence of adverse events were compared between the two groups.Result At the completion of radiotherapy and three months after radiotherapy,the objective response rate(ORR)of the study group were 92.68%and 90.24%,which were higher than 73.17%and 68.29%of the control group,and the differ-ences were statistically significant(P<0.05).The rectal Dmax,small intestinal Dmax,and bladder D2cc in the study group were significantly lower than those in the control group(P<0.01).The external irradiation time and overall treatment comple-tion time in the study group were shorter than those in the control group(P<0.01).The incidence of bone marrow suppres-sion in the study group was 34.15%,which was lower than 65.85%in the control group(P<0.01).Conclusion Com-pared with late course dose escalation intensity-modulated radiotherapy,synchronous dose escalation intensity-modulated radiotherapy can improve the clinical efficacy of cervical cancer patients with pelvic and abdominal lymph node metasta-sis,shorten treatment time,reduce radiation dose to organs at risk and the incidence of bone marrow suppression.
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