Objective To investigate the expression and clinical significance of pro-gastrin-releasing peptide(ProGRP)and squamous cell carcinoma antigen(SCCA)in non-small cell lung cancer(NSCLC).Method A total of 122 NSCLC patients and 93 healthy subjects were selected as the observation group and the control group.The serum ProGRP and SCCA levels in the two groups were detected by chemiluminescence method.The levels and positive expres-sion rates of ProGRP and SCCA in NSCLC patients with different histological types were compared,the positive expres-sion rates of ProGRP and SCCA in the two groups and NSCLC patients with different clinical features were also com-pared.Draw the receiver operating characteristic(ROC)curve,calculate the area under the curve(AUC),and evaluate the diagnostic value of ProGRP and SCCA single and combined detection for NSCLC.Result The serum SCCA level in squamous cell carcinoma patients were higher than those in adenocarcinoma and large cell carcinoma patients,and the dif-ferences were statistically significant(P<0.05).The positive expression rate of SCCA in squamous cell carcinoma pa-tients was higher than that in adenocarcinoma patients,and the difference was statistically significant(P<0.05).The posi-tive expression rates of ProGRP and SCCA in the observation group were 90.98%and 78.69%,which were significantly higher than 8.60%and 6.45%in the control group,and the differences were statistically significant(P<0.01).The positive expression rates of ProGRP and SCCA in NSCLC patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,and the differences were statistically significant(P<0.01).ROC curve showed that the AUC of ProGRP combined with SCCA detection for the diagnosis of NSCLC was 0.797(95%CI:0.714-0.880),the sensitivity was 90.59%,and the specificity was 89.25%,which were higher than the individual detection.Con-clusion The positive expression rates of ProGRP and SCCA in NSCLC patients are high,and their expression are associ-ated with lymph node metastasis.ProGRP and SCCA combined detection has high diagnostic value for NSCLC.
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