Analysis of the application effect and cerebral protective effect of different doses of dexmedetomidine on patients with thyroid cancer undergoing surgery
Objective To analyze the application effect and cerebral protective effect of different doses of dexmedeto-midine on patients with thyroid cancer undergoing surgery.Method A total of 300 patients with thyroid cancer were se-lected and divided into high dose group,low dose group and control group according to different doses of dexmedetomi-dine,with 100 cases in each group.All patients were received radical thyroidectomy after intravenous general anesthesia.After induction of anesthesia,high and low dose groups were received 10 ml 1.0 μg/kg and 0.5 μg/kg dexmedetomidine injection intravenously,and control group was received 10 ml 0.9%sodium chloride injection.The hemodynamic indexes[mean arterial pressure(MAP),pulse blood oxygen saturation(SpO2),heart rate(HR)],anesthesia-related indexes,analge-sic effect,cerebral protective effect indexes[neuron specific enolase(NSE),glial fibrillary acidic protein(GFAP),soluble protein 100β(S100β)]and adverse reactions were compared among the three groups.Result Before anesthesia(T0),dur-ing anesthesia induction(T1),during 15 minutes after surgery(T2),during lesion resection(T3),during surgical suturing(T4),MAP and HR in high and low dose groups were significantly lower than those in control group,and SpO2 were sig-nificantly higher than those in control group,and the differences were statistically significant(P<0.01).The awakening time,consciousness recovery time,tracheal extubation time and recovery room stay time in high and low dose groups were significantly shorter than those in control group,and the differences were statistically significant(P<0.01).At 1,2,4,12 h after surgery,visual analogue scale(VAS)scores in high and low dose groups were significantly lower than those in control group,and Ramsay scores were significantly higher than those in control group,and the differences were statis-tically significant(P<0.01).At 24 h after surgery,NSE,GFAP and S100β levels in high and low dose groups were signifi-cantly lower than those in control group,and the differences were statistically significant(P<0.01).The total incidence of adverse reactions in high dose group was significantly higher than those in low dose group and control group,and the dif-ferences were statistically significant(P<0.01).Conclusion Dexmedetomidine has a good application effect on patients with thyroid cancer undergoing surgery,which can improve the hemodynamics of patients during surgery,promote rapid recovery of patients after surgery,has good analgesic and cerebral protective effect,and small dose of dexmedetomidine has better safety and can be recommended in clinical practice.
万方数据
维普
