Effect of targeted intervention on postoperative inflammatory response and recovery process in patients with endometrial cancer
Objective To investigate the effect of targeted intervention on postoperative inflammatory response and recovery process in patients with endometrial cancer.Method A total of 106 patients with endometrial cancer were di-vided into conventional group and target group according to different intervention methods,with 53 cases in each group.Patients in the conventional group were given routine perioperative intervention,and patients in the target group were giv-en targeted intervention.Clinical indicators,serum inflammatory response indicators[C-reactive protein(CRP),tumor ne-crosis factor-α(TNF-α),interleukin-6(IL-6)],oxidative stress indicators[advanced oxidized protein product(AOPP),re-active oxygen species(ROS),malondialdehyde(MDA)],serum trauma markers[total antioxidant capacity(TAC),myo-globin(MYO),ischaemic modified albumin(IMA)]were compared between the two groups.The incidence of postopera-tive complications in the two groups were analyzed before discharge.Result The postoperative exhaust time,start bed-side activity time,catheterization time and hospital stay in the target group were significantly shorter than those in the con-ventional group,the differences were statistically significant(P<0.01).After surgery,the serum levels of CRP,TNF-α and IL-6 in two groups were higher than those before surgery,but the levels of CRP,TNF-α and IL-6 in target group were low-er than those in conventional group,the differences were statistically significant(P<0.05).After surgery,serum TAC lev-els in two groups were lower than those before surgery,MYO and IMA levels were higher than those before surgery,but TAC level in target group was higher than that in conventional group,MYO and IMA levels were lower than those in con-ventional group,the differences were statistically significant(P<0.05).After surgery,serum AOPP,ROS and MDA levels in the two groups were higher than those before surgery,but AOPP,ROS and MDA levels in target groups were lower than those in conventional group,the differences were statistically significant(P<0.05).The total incidence of complica-tions in targeted group was lower than that in conventional group,and the difference was statistically significant(P<0.05).Conclusion Targeted intervention can reduce the inflammatory response and oxidative stress response of patients with endometrial cancer,improve the levels of serum trauma markers,shorten the postoperative recovery process,and help improve the safety of surgery.
endometrial cancersurgeryinflammatory responseoxidative stress reactionpostoperative recovery process
万方数据
维普
