Relationship between serum thyroid hormone levels and different tumor metastasis
Objective To investigate the differences of thyroid hormone levels in patients with different tumors and analyze the correlation between thyroid hormone levels and tumor metastases.Method The medical records of 713 pa-tients with solid tumor and 309 healthy subjects were collected,and the thyroid hormone levels in patients with different metastases and healthy subjects were compared.The correlation analysis method was used to analyze the correlation be-tween thyroid hormone levels and lipid metabolism indexes in patients with metastases and without metastases.Result The levels of thyroid stimulating hormone(TSH),triiodothyronine(T3),free triiodothyronine(FT3)and free thyroxine(FT4)in tumor patients were significantly lower than those in healthy subjects,the differences were statistically signifi-cant(P＜0.01).Among 713 tumor patients,317(44.46％)had metastasis.TSH,thyroxine(T4),T3 and FT3 in patients with metastatic pituitary tumor were lower than those without metastasis,TSH and FT4 in patients with metastatic lung cancer were lower than those without metastasis,T4 in patients with metastatic esophageal cancer was lower than that without metastasis,and T4 and FT4 in patients with metastatic liver cancer were lower than those without metastasis,the differenc-es were statistically significant(P＜0.05).The levels of total cholesterol(TC)and low density lipoprotein(LDL)in tumor patients were significantly higher than those in healthy subjects,the differences were statistically significant(P＜0.01).The levels of TC and LDL in patients with metastatic pituitary tumor,lung cancer,esophageal cancer and liver cancer were significantly higher than those in non-metastatic patients,the differences were statistically significant(P＜0.01).FT3 in pituitary tumor patients,FT4 in lung cancer patients,T4 in esophageal cancer patients and T4 in liver cancer patients were negatively correlated with TC and LDL.Conclusion T4,FT3 and FT4 are correlated with metastasis of lung cancer,esophageal cancer,pituitary tumor and liver cancer.The decrease of T4,FT3 and FT4 may affect the balance of lipid metab-olism by increasing TC and LDL,promote tumor metastasis,and lead to increased risk of metastasis of lung cancer,esophageal cancer,pituitary tumor,and liver cancer.
万方数据
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