Objective To investigate the prognosis and its influencing factors of cutaneous melanoma(CM).Method The expression of vimentin,S100,HMB45,Ki-67 and Melan-A in 481 CM patients were detected by immunohistochemi-cal method.All CM patients were followed up and divided into the survival group and the death group according to the prognosis.The influencing factors of prognosis in CM patients were analyzed by Cox proportional hazards model.Result The 481 patients with CM were followed up for 1-132 months,265 patients died and 216 patients survived,and the over-all survival rate was 44.91％.Univariate analysis showed that there were statistically significant differences in ulcer sta-tus,Clark grade,lymph node metastasis,S100 expression,Ki-67 expression between the two groups(P＜0.01).Multi-variate analysis showed that Clark grade was not an influencing factor of prognosis in CM patients(P＞0.05),and ul-cer,lymph node metastasis,S100(+++)and Ki-67≥30％were risk factors for the prognosis of CM patients(P＜0.05).Conclusion The prognosis of CM patients is poor.Ulceration,lymph node metastasis,S100(+++)and Ki-67≥30％are risk factors for the prognosis of CM patients,which can be used to evaluate the prognosis of CM patients and help to se-lect clinical treatment plans to improve the survival rate of patients.
维普
万方数据