Objective To investigate the application effect of intravesical chemotherapy with gemcitabine in postoper-ative patients with non-muscle-invasive bladder cancer.Method A total of 120 patients with non-muscle-invasive blad-der cancer were divided into control group and observation group according to different treatment methods,with 60 cases in each group.All patients received surgical treatment,patients in the control group received postoperative intravesical chemotherapy with pirarubicin,patients in the observation group received postoperative intravesical chemotherapy with gemcitabine.The clinical efficacy,tumor markers[serum carcinoembryonic antigen(CEA),urinary fibrinogen degrada-tion product(FDP)],quality of life[European Organization for Research and Treatment of Cancer quality of life question-naire core 30(EORTC QLQ-C30)]and adverse reactions were compared between the two groups.Result The disease control rate of the observation group was 88.33％,which was significantly higher than 68.33％of the control group,and the difference was statistically significant(P＜0.01).After treatment,the serum CEA and urinary FDP levels in the two groups were lower than those before treatment,and the serum CEA and urinary FDP levels in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the scores of physical function,role function,social function and overall health in the two groups were higher than those be-fore treatment,and the scores in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion Intravesical chemotherapy with gemcitabine can improve the clinical effica-cy and quality of life of postoperative patients with non-muscle-invasive bladder cancer,reduce the levels of tumor mark-ers,and has good safety.
关键词
非肌层浸润性膀胱癌/吉西他滨/膀胱灌注化疗/临床疗效/肿瘤标志物/生活质量
Key words
non-muscle-invasive bladder cancer/gemcitabine/intravesical chemotherapy/clinical efficacy/tumor marker/quality of life
维普
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