Relationship between the levels of serum lactate dehydrogenase,β2-microglo-bulin,ferritin and prognosis in patients with invasive B-cell lymphoma
Objective To explore the relationship between serum lactate dehydrogenase(LDH),β2-microglobulin(β2-MG),ferritin levels and prognosis in patients with invasive B-cell lymphoma.Method A total of 60 patients with inva-sive B-cell lymphoma were selected,all patients received rituximab+cyclophosphamide+epirubicin+vincristine+prednisone(R-CHOP)regimen chemotherapy.The therapeutic effect was evaluated after 4 courses of treatment,and lev-els of serum LDH,β2-MG,and ferritin levels were detected before and after treatment.Followed up for 3 years,the serum LDH,β2-MG,and ferritin levels in patients with invasive B-cell lymphoma with different prognosis after 4 courses of treatment were compared,and their correlation with patients prognosis was analyzed by Spearman rank correlation analy-sis.Result After 4 courses of treatment,in 60 patients with invasive B-cell lymphoma,38 cases showed complete re-sponse,7 cases showed partial response,4 cases showed stable disease,and 11 cases showed progressive disease,the dis-ease control rate was 81.67％(49/60).After 4 courses of treatment,the serum LDH,β2-MG and ferritin levels in patients with invasive B-cell lymphoma were significantly lower than those before treatment,the differences were statistically sig-nificant(P＜0.01).Followed up for 3 years,there was no loss of follow-up for all patients,with 43 surviving cases and 17 death cases.The serum LDH,β2-MG,and ferritin levels of surviving patients after 4 courses of treatment were significant-ly lower than those of death patients,and the differences were statistically significant(P＜0.01).Spearman rank correla-tion analysis results showed that serum LDH,β2-MG,and ferritin levels were negatively correlated with the prognosis sur-vival of patients with invasive B-cell lymphoma(r=-0.718,-0.823,-0.753,P＜0.05).Conclusion Levels of serum LDH,β2-MG,and ferritin are negatively correlated with the prognosis survival of patients with invasive B-cell lymphoma,which helps to objectively evaluate the prognosis of patients in clinical practice.
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